New Testosterone Buccal System (Striant) Delivers Physiological Testosterone Levels: Pharmacokinetics Study in Hypogonadal Men (2004)
*In conclusion, administration of T by buccal administration consistently maintained the mean serum T concentration within the physiologic range in most hypogonadal men. Because there is no dose adjustment, the one dose of 30 mg twice per day may provide insufficient or alternatively elevated serum T levels for some hypogonadal men. The application of the TBS caused mild to moderate gum irritation in some men that resulted in discontinuation in only 3% of subjects. The new dosage form was well accepted by the subject population. This novel T delivery system offers a viable alternative to the currently available methods for physiological replacement in hypogonadal men.