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Yeah, I like to think about these things having a physiology background myself.  Sorry if it was overkill.  I'm not sitting in a room pulling my hair out over what to do next for myself.  I realize that the bottom line is that every protocol has its trade offs, and every individual is different, and at the end of the day you go with what works.   But maybe by delving into the underlying physiology, we can better optimize protocols, and better help guys with E2 issues or DHT issues or SHBG issues.