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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SubQ vs IM (E2)
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<blockquote data-quote="Cataceous" data-source="post: 219686" data-attributes="member: 38109"><p>If you were injecting straight testosterone then having it encounter and interact with more aromatase in fatty tissue would at least be a theoretical possibility. However, testosterone esters such as testosterone cypionate are essentially inert at the injection sites; they cannot be aromatized. Instead they must be absorbed, and only when they reach the bloodstream do they encounter enzymes that strip off the esters, leaving the biologically active testosterone free to interact with aromatase, SHBG, androgen receptors, etc.</p><p></p><p>The absorption mechanisms for subcutaneous and intramuscular injected depots are somewhat different. This leads to differing rates of absorption, which in turn are reflected in differing levels of serum testosterone over time. The data suggest that in general IM depots absorb faster than SC depots. This means that serum testosterone with IM goes up faster and higher, but also drops sooner and lower. You get higher peaks and lower troughs, but overall the same amount of testosterone is delivered at the same dose, so that average levels are the same between IM and SC. The differing serum levels are reflected in metabolites such as estradiol. The expectation is that at pre-injection troughs the level of estradiol is higher with SC injections than with IM injections. However, the opposite is expected at peak serum levels.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 219686, member: 38109"] If you were injecting straight testosterone then having it encounter and interact with more aromatase in fatty tissue would at least be a theoretical possibility. However, testosterone esters such as testosterone cypionate are essentially inert at the injection sites; they cannot be aromatized. Instead they must be absorbed, and only when they reach the bloodstream do they encounter enzymes that strip off the esters, leaving the biologically active testosterone free to interact with aromatase, SHBG, androgen receptors, etc. The absorption mechanisms for subcutaneous and intramuscular injected depots are somewhat different. This leads to differing rates of absorption, which in turn are reflected in differing levels of serum testosterone over time. The data suggest that in general IM depots absorb faster than SC depots. This means that serum testosterone with IM goes up faster and higher, but also drops sooner and lower. You get higher peaks and lower troughs, but overall the same amount of testosterone is delivered at the same dose, so that average levels are the same between IM and SC. The differing serum levels are reflected in metabolites such as estradiol. The expectation is that at pre-injection troughs the level of estradiol is higher with SC injections than with IM injections. However, the opposite is expected at peak serum levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SubQ vs IM (E2)
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