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Testosterone Replacement, Low T, HCG, & Beyond
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<blockquote data-quote="madman" data-source="post: 159629" data-attributes="member: 13851"><p>Hope you understand that when injected sub-q the esterified T does not convert to E2 until the ester has been cleaved......which mainly happens when it enters the bloodstream and as stated below....<em>.<strong>"</strong></em><span style="color: rgb(26, 188, 156)"><strong><em><strong>Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed"</strong></em></strong></span></p><p></p><p><strong><em>"PRODRUG HYDROLYSIS WILL ONLY OCCUR IN BLOOD"</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>CONCLUSIONS </strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)"><em>It is interesting to realize that drug absorption from an oil depot cannot entirely be described by a simple two-phase mass transfer model where concentration gradients, diffusion, and partition coefficients would enable the calculation of the expected absorption.</em></span></strong><em> <span style="color: rgb(44, 130, 201)"><strong>It is demonstrated in this dissertation that there is a role of the excipient BOH in yielding an initially high absorption.</strong></span> <span style="color: rgb(26, 188, 156)"><strong>The oil depot forms a continuous phase after injection but will be dispersed and encapsulated at the injection site after some days. This in turn largely influences the way the prodrug becomes available; after release from the oil depot, it is present in the interstitial fluid which is drained through the lymph into the systemic circulation. Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed. </strong></span><span style="color: rgb(251, 160, 38)"><strong>Both the lymph transport and the cell wall permeation take time which is expressed in a lag time. This lag time is different for each injection site: </strong></span><span style="color: rgb(147, 101, 184)"><strong>a subcutaneously administered prodrug will enter the systemic circulation via a short path and at a low drainage flow. This results in a short lag time and a slow absorption rate constant of the prodrug.</strong></span> <span style="color: rgb(0, 0, 0)"><strong>Deeper administered prodrugs (i.e. intramuscular injections) are suggested to be absorbed via a longer path, but at a higher flow, which results in a longer lag time but a higher absorption rate constant of the prodrug.</strong></span></em></p><p></p><p>[ATTACH=full]8327[/ATTACH]</p><p><strong><span style="color: rgb(184, 49, 47)">Figure 7.2:</span><u> Schematic overview of the new insights into drug absorption from oil depots</u>. </strong><span style="color: rgb(250, 197, 28)"><strong>After release from the oil depot (yellow circle at the injection site),</strong></span> <strong><span style="color: rgb(44, 130, 201)">the prodrug is transferred towards the central compartment via the lymphatic system.</span><span style="color: rgb(26, 188, 156)"> Here, it will be hydrolyzed to the active substance (see circle).</span> ka = absorption rate constant; ke = elimination rate constant. </strong></p></blockquote><p></p>
[QUOTE="madman, post: 159629, member: 13851"] Hope you understand that when injected sub-q the esterified T does not convert to E2 until the ester has been cleaved......which mainly happens when it enters the bloodstream and as stated below....[I].[B]"[/B][/I][COLOR=rgb(26, 188, 156)][B][I][B]Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed"[/B][/I][/B][/COLOR] [B][I]"PRODRUG HYDROLYSIS WILL ONLY OCCUR IN BLOOD"[/I] CONCLUSIONS [COLOR=rgb(184, 49, 47)][I]It is interesting to realize that drug absorption from an oil depot cannot entirely be described by a simple two-phase mass transfer model where concentration gradients, diffusion, and partition coefficients would enable the calculation of the expected absorption.[/I][/COLOR][/B][I] [COLOR=rgb(44, 130, 201)][B]It is demonstrated in this dissertation that there is a role of the excipient BOH in yielding an initially high absorption.[/B][/COLOR] [COLOR=rgb(26, 188, 156)][B]The oil depot forms a continuous phase after injection but will be dispersed and encapsulated at the injection site after some days. This in turn largely influences the way the prodrug becomes available; after release from the oil depot, it is present in the interstitial fluid which is drained through the lymph into the systemic circulation. Subsequently, the prodrug permeates through the wall of blood cells and is hydrolyzed. [/B][/COLOR][COLOR=rgb(251, 160, 38)][B]Both the lymph transport and the cell wall permeation take time which is expressed in a lag time. This lag time is different for each injection site: [/B][/COLOR][COLOR=rgb(147, 101, 184)][B]a subcutaneously administered prodrug will enter the systemic circulation via a short path and at a low drainage flow. This results in a short lag time and a slow absorption rate constant of the prodrug.[/B][/COLOR] [COLOR=rgb(0, 0, 0)][B]Deeper administered prodrugs (i.e. intramuscular injections) are suggested to be absorbed via a longer path, but at a higher flow, which results in a longer lag time but a higher absorption rate constant of the prodrug.[/B][/COLOR][/I] [ATTACH type="full" alt="Screenshot (600).png"]8327[/ATTACH] [B][COLOR=rgb(184, 49, 47)]Figure 7.2:[/COLOR][U] Schematic overview of the new insights into drug absorption from oil depots[/U]. [/B][COLOR=rgb(250, 197, 28)][B]After release from the oil depot (yellow circle at the injection site),[/B][/COLOR] [B][COLOR=rgb(44, 130, 201)]the prodrug is transferred towards the central compartment via the lymphatic system.[/COLOR][COLOR=rgb(26, 188, 156)] Here, it will be hydrolyzed to the active substance (see circle).[/COLOR] ka = absorption rate constant; ke = elimination rate constant. [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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