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But with ONCE WEEKLY injections (especially SubQ), you would likely have much LESS sawtooth effect than with multiple more frequent injections. I fail to see how a once weekly injection would produce more sawtooth effect than smaller more frequent injections... there is no physiologic or pharmacodynamic explanation for that, regardless of an open or closed system. It cannot happen.

Larger once weekly injections would produce a more broad sloping "sawtooth" pattern like a very dull saw, while more frequent injections would produce more frequent "points" on that saw blade...this is all assuming that the sawtooth pattern is indeed ideal, which some would debate as well but I agree VARIATION (sawtooth if you want to call it that) is good, how much variation or the extent of that variation (hourly variation, daily variation, weekly variation, etc) that is optimal is another question, although hourly variation most closely approximates the biological system but is unfortunately only approximated treatment-wise by topicals... let's create the perfect TRT modality/route, dominate the TRT field, and then buy an island to rename "The Man Island- but Women Welcome!"...lol

Dr Saya

Dr Saya