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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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<blockquote data-quote="Cataceous" data-source="post: 207994" data-attributes="member: 38109"><p>Anecdotal evidence has its uses, but there are circumstances in which relying on it leads to incorrect conclusions. In general the anecdotes should lead to hypotheses, which in turn are tested under controlled conditions.</p><p></p><p>The nature of this evidence is weak. As I've said before, the problems include: single samples during an injection cycle, which do not reflect overall absorption; no controlling for changes in SHBG; no mention of inspections for site leakage; no independent verification that the same labs and testing methodologies were used.</p><p></p><p>However, hypotheses in this situation are clearly labeled as such and none is blatantly contradicted by existing studies. On the contrary, the hypotheses are largely derived from existing research.</p><p></p><p>To be clear, here's what's being shot down:</p><p></p><p>•The claim that less total testosterone is absorbed via SC delivery compared to IM</p><p>•The claim that most men will fare worse with SC than with IM injections</p><p>•The claim that most men need more than 100 mg per week of testosterone cypionate/enanthate in TRT</p><p></p><p>And here's what's not:</p><p></p><p>•The claim that different subjective results may be observed between IM and SC</p><p>•The claim that different absorption patterns may be observed between IM and SC</p><p>•The claim that more injection site leakage is possible with SC compared to IM</p></blockquote><p></p>
[QUOTE="Cataceous, post: 207994, member: 38109"] Anecdotal evidence has its uses, but there are circumstances in which relying on it leads to incorrect conclusions. In general the anecdotes should lead to hypotheses, which in turn are tested under controlled conditions. The nature of this evidence is weak. As I've said before, the problems include: single samples during an injection cycle, which do not reflect overall absorption; no controlling for changes in SHBG; no mention of inspections for site leakage; no independent verification that the same labs and testing methodologies were used. However, hypotheses in this situation are clearly labeled as such and none is blatantly contradicted by existing studies. On the contrary, the hypotheses are largely derived from existing research. To be clear, here's what's being shot down: •The claim that less total testosterone is absorbed via SC delivery compared to IM •The claim that most men will fare worse with SC than with IM injections •The claim that most men need more than 100 mg per week of testosterone cypionate/enanthate in TRT And here's what's not: •The claim that different subjective results may be observed between IM and SC •The claim that different absorption patterns may be observed between IM and SC •The claim that more injection site leakage is possible with SC compared to IM [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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