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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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<blockquote data-quote="Cataceous" data-source="post: 206509" data-attributes="member: 38109"><p>Let me clarify this: At steady state the rate of excretion is determined by the dose. So even after a large change in SHBG, when a new equilibrium is reached the rate of excretion must be the same as before the change. The rate of excretion is driven directly by free testosterone, so free testosterone must also return to its previous value. Because of these effects it is total testosterone that becomes the dependent variable. A sudden decrease in SHBG transiently pushes up free testosterone, which acts to lower total testosterone until free testosterone is forced back to the level needed for excretion to match the rate of testosterone input.</p><p></p><p>Regarding other possible explanations for your results, incomplete absorption is very improbable. Aside from the controlled studies showing no such problems, there's the lack of a plausible mechanism for the testosterone to seemingly disappear. Injection site leakage is possible, though it would need to be a regular occurrence, which would make it harder to miss. You suggest unusually slow absorption as a possibility, but unusually fast absorption is a better fit. In the case of slow absorption it is still going to raise your levels eventually. With fast absorption your high peaks pass before you take your measurements. This is why I emphasize that multiple measurements are needed to evaluate area under the curve.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 206509, member: 38109"] Let me clarify this: At steady state the rate of excretion is determined by the dose. So even after a large change in SHBG, when a new equilibrium is reached the rate of excretion must be the same as before the change. The rate of excretion is driven directly by free testosterone, so free testosterone must also return to its previous value. Because of these effects it is total testosterone that becomes the dependent variable. A sudden decrease in SHBG transiently pushes up free testosterone, which acts to lower total testosterone until free testosterone is forced back to the level needed for excretion to match the rate of testosterone input. Regarding other possible explanations for your results, incomplete absorption is very improbable. Aside from the controlled studies showing no such problems, there's the lack of a plausible mechanism for the testosterone to seemingly disappear. Injection site leakage is possible, though it would need to be a regular occurrence, which would make it harder to miss. You suggest unusually slow absorption as a possibility, but unusually fast absorption is a better fit. In the case of slow absorption it is still going to raise your levels eventually. With fast absorption your high peaks pass before you take your measurements. This is why I emphasize that multiple measurements are needed to evaluate area under the curve. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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