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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
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<blockquote data-quote="Cataceous" data-source="post: 206466" data-attributes="member: 38109"><p>Biological systems may result in noisy data, but it's still possible to support or refute hypotheses with well run studies.</p><p></p><p>At least one large study has shown that free testosterone is proportional to dose. This principle should apply to anyone on TRT. It's easiest to observe with frequent injections where testosterone levels are not changing much between doses. If someone is only injecting once or twice a week then there's a lot more noise in the measurements, and ideally you'd average areas under the curves for a few weeks to get good data. This is impractical for the vast majority of individuals. However, on EOD enanthate I was able to obtain very linear data involving several different doses.</p><p></p><p>If you raise your dose by 20 mg/week then free testosterone increases in proportion to the extra testosterone. If at the same time you independently lower your SHBG by a sufficient amount then it is possible to have total testosterone go lower. Of course this would be somewhat unusual. Here's an example relying on the Vermeulen free T calculator:</p><p></p><p>Joe Average takes in 6.5 mg testosterone per day and has a total testosterone of 650 ng/dL. His SHBG is 30 nMol/L and his free testosterone is 15 ng/dL. From this and the free T calculator we infer that his free testosterone in ng/mL may be computed as 15/6.5 * daily_T_intake. Now add 20 mg per week of testosterone cypionate to his intake. This is an extra 2 mg/day of testosterone. His new free T is 15/6.5 * 8.5 = 19.6 ng/dL. What if he halves his SHBG to 15 nMol/L at the same time? Using the free T calculator we find that total testosterone has dropped to 632 ng/dL.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 206466, member: 38109"] Biological systems may result in noisy data, but it's still possible to support or refute hypotheses with well run studies. At least one large study has shown that free testosterone is proportional to dose. This principle should apply to anyone on TRT. It's easiest to observe with frequent injections where testosterone levels are not changing much between doses. If someone is only injecting once or twice a week then there's a lot more noise in the measurements, and ideally you'd average areas under the curves for a few weeks to get good data. This is impractical for the vast majority of individuals. However, on EOD enanthate I was able to obtain very linear data involving several different doses. If you raise your dose by 20 mg/week then free testosterone increases in proportion to the extra testosterone. If at the same time you independently lower your SHBG by a sufficient amount then it is possible to have total testosterone go lower. Of course this would be somewhat unusual. Here's an example relying on the Vermeulen free T calculator: Joe Average takes in 6.5 mg testosterone per day and has a total testosterone of 650 ng/dL. His SHBG is 30 nMol/L and his free testosterone is 15 ng/dL. From this and the free T calculator we infer that his free testosterone in ng/mL may be computed as 15/6.5 * daily_T_intake. Now add 20 mg per week of testosterone cypionate to his intake. This is an extra 2 mg/day of testosterone. His new free T is 15/6.5 * 8.5 = 19.6 ng/dL. What if he halves his SHBG to 15 nMol/L at the same time? Using the free T calculator we find that total testosterone has dropped to 632 ng/dL. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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