ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sub Q injections quit working
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 206456" data-attributes="member: 38109"><p>I should be qualifying it as a hypothesis, but it pretty much falls out of the law of mass action. The primary assumption is that underlying steroid metabolism is basically static over the time frame of interest. Another interesting feature is that the rate at which—exogenous or endogenous—testosterone enters our system directly drives free testosterone, not total. If SHBG isn't changing much then the proportionality can appear to apply to total testosterone also. </p><p></p><p>Consider a thought experiment: We can infuse a test subject with testosterone at a fixed rate. Assume no endogenous production. At steady state we know that however much testosterone we're putting in, the same amount is being metabolized and eliminated. For example, if we're infusing at a rate of 10 mg T per day then the subject is also metabolizing 10 mg T per day. In accordance with the <a href="https://en.wikipedia.org/wiki/Law_of_mass_action" target="_blank">law of mass action</a>, the rate of metabolism is proportional to the concentration of free testosterone; bound testosterone cannot be metabolized directly. Therefore free testosterone is proportional to the dose rate.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 206456, member: 38109"] I should be qualifying it as a hypothesis, but it pretty much falls out of the law of mass action. The primary assumption is that underlying steroid metabolism is basically static over the time frame of interest. Another interesting feature is that the rate at which—exogenous or endogenous—testosterone enters our system directly drives free testosterone, not total. If SHBG isn't changing much then the proportionality can appear to apply to total testosterone also. Consider a thought experiment: We can infuse a test subject with testosterone at a fixed rate. Assume no endogenous production. At steady state we know that however much testosterone we're putting in, the same amount is being metabolized and eliminated. For example, if we're infusing at a rate of 10 mg T per day then the subject is also metabolizing 10 mg T per day. In accordance with the [URL='https://en.wikipedia.org/wiki/Law_of_mass_action']law of mass action[/URL], the rate of metabolism is proportional to the concentration of free testosterone; bound testosterone cannot be metabolized directly. Therefore free testosterone is proportional to the dose rate. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sub Q injections quit working
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top