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Study shows lower Alzheimer's risk in Viagra users
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<blockquote data-quote="Cataceous" data-source="post: 213129" data-attributes="member: 38109"><p>What's nice is that the correlation suggests the animal models might be applicable.</p><p></p><p style="margin-left: 20px"><em>Specifically, various rodent studies have reported that PDE5 inhibitors can reverse cognitive impairments and pathology in aged wild-type mice and transgenic Alzheimer’s mouse models through mechanisms including reduced tau hyperphosphorylation (via GSK3β activation), increased BDNF, anti- inflammatory action, increased pCREB signaling, and reduced apoptosis and cell death [2; 3; 4; 5]. Beta- amyloid pathology has been reversed in some [3; 6] but not all [2; 5] studies.</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Whether these effects will occur in humans has yet to be tested. No human studies, observational or randomized, have examined if the use of PDE5 inhibitors can protect against dementia or brain aging.</em></p><p>[URL unfurl="true"]https://www.alzdiscovery.org/uploads/cognitive_vitality_media/PDE5-inhibitors-Cognitive-Vitality-For-Researchers.pdf[/URL]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 213129, member: 38109"] What's nice is that the correlation suggests the animal models might be applicable. [INDENT][I]Specifically, various rodent studies have reported that PDE5 inhibitors can reverse cognitive impairments and pathology in aged wild-type mice and transgenic Alzheimer’s mouse models through mechanisms including reduced tau hyperphosphorylation (via GSK3β activation), increased BDNF, anti- inflammatory action, increased pCREB signaling, and reduced apoptosis and cell death [2; 3; 4; 5]. Beta- amyloid pathology has been reversed in some [3; 6] but not all [2; 5] studies.[/I][/INDENT] [INDENT][/INDENT] [INDENT][I]Whether these effects will occur in humans has yet to be tested. No human studies, observational or randomized, have examined if the use of PDE5 inhibitors can protect against dementia or brain aging.[/I][/INDENT] [URL unfurl="true"]https://www.alzdiscovery.org/uploads/cognitive_vitality_media/PDE5-inhibitors-Cognitive-Vitality-For-Researchers.pdf[/URL] [/QUOTE]
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General Health & Fitness
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Study shows lower Alzheimer's risk in Viagra users
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