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Very good writeup my friend.  I agree with you. 


I enjoyed your answer, although, what I was asking about is the meaning of this specific language...

Compared with nonuse, current use of TRT was associated with an increased risk of the composite outcome (HR 1.21; 95% CI, 1.00-1.46). 


Does HR 1.21 mean that the TRT user group experienced a 21% increase in adverse events? 


PS, Sorry I wasn't more clear in wording my question.


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