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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Study Finds Increased Risk of CVD from TRT
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<blockquote data-quote="xqfq" data-source="post: 154306" data-attributes="member: 38167"><p>This was a cohort study done using health data that’s available in the UK. So I don’t think researchers gave a specific TRT protocol, etc. They searched this database for people on TRT and then looked at their outcomes over a period of time. This is important because there could be huge variations in terms of how treatment was delivered and how health was monitored.</p><p></p><p>The abstract notes that the risk increase was only seen in the first two years of TRT. This makes me think that — if this risk increase was due to TRT usage and not factors in the hypogonadal subpopulation — that it’s related to increases in hematocrit and blood pressure (rather than, say, dyslipidemia / lowering of HDL in some men in some cases).</p><p></p><p>As we know, hypogonadal men are at increased CVD risk. So there may have been a selection problem here, meaning that this subpopulation may have already been at higher risk than baseline, regardless of TRT usage. And this risk could have built over many years, meaning TRT may not have done much to reduce the aggregate risk. I would want to see if the study accounted for this with a control group consisting of hypogonadal men not on TRT, but I suspect that data simply wasn’t available in their data set as “TRT usage” may have been their “is hypogonadal?” check. But I’d need the full article to see .</p><p></p><p>Regardless of control group, men seeking out TRT may also have other characteristics that make them more likely to get CVD. In simple terms, they might be sicker or more unhealthy than the baseline population, and possibly sicker than even the baseline hypogonadal population. Because this wasn’t an interventional study (the researchers didn’t select people and then give them TRT), this is a possibility.</p></blockquote><p></p>
[QUOTE="xqfq, post: 154306, member: 38167"] This was a cohort study done using health data that’s available in the UK. So I don’t think researchers gave a specific TRT protocol, etc. They searched this database for people on TRT and then looked at their outcomes over a period of time. This is important because there could be huge variations in terms of how treatment was delivered and how health was monitored. The abstract notes that the risk increase was only seen in the first two years of TRT. This makes me think that — if this risk increase was due to TRT usage and not factors in the hypogonadal subpopulation — that it’s related to increases in hematocrit and blood pressure (rather than, say, dyslipidemia / lowering of HDL in some men in some cases). As we know, hypogonadal men are at increased CVD risk. So there may have been a selection problem here, meaning that this subpopulation may have already been at higher risk than baseline, regardless of TRT usage. And this risk could have built over many years, meaning TRT may not have done much to reduce the aggregate risk. I would want to see if the study accounted for this with a control group consisting of hypogonadal men not on TRT, but I suspect that data simply wasn’t available in their data set as “TRT usage” may have been their “is hypogonadal?” check. But I’d need the full article to see . Regardless of control group, men seeking out TRT may also have other characteristics that make them more likely to get CVD. In simple terms, they might be sicker or more unhealthy than the baseline population, and possibly sicker than even the baseline hypogonadal population. Because this wasn’t an interventional study (the researchers didn’t select people and then give them TRT), this is a possibility. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Study Finds Increased Risk of CVD from TRT
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