Study Conclusions Reversed: HRT vindicated in new JAMA article

Nelson Vergel

Founder, ExcelMale.com
A new article in JAMA (September 12, 2017) reverses the outcome of the (2002) WHI study that brought the entire Hormone Replacement Therapy (HRT) field to its knees by reviewing all-cause mortality of the 27,000 women followed for eighteen years who were the original study participants. According to the statistical review by the principal investigators of the 2002 WHI study, the women who were taking hormones (non bioidentical, only Premarin and Provera) did not die earlier or have higher incidence of chronic illnesses than those taking placebo. In fact, because they took hormones, they did better than the women on placebo by improving the quality of their lives, even preventing osteoporosis, heart disease and Alzheimers, increasing sexual satisfaction and eliminating hot flashes and night sweats.

But the medical establishment knew that in the 1960s, 70s, 80s and even 90s. HRT was evidence based state of the art treatment for menopause then. Not giving women HRT would have been considered medically improper then.

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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