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Studies on fish oil
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<blockquote data-quote="Vince" data-source="post: 96408" data-attributes="member: 843"><p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">Higher fish consumption/omega-3 intake inversely associated with cognitive decline ages 45-70 years:<a href="https://www.ncbi.nlm.nih.gov/pubmed/14745067" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/14745067</a></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">Higher plasma omega-3 levels associated with less decline in selected measures of cognitive function (sensorimotor speed) but not in memory or word fluency over 3 years, ages 50-70:</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">https://www.ncbi.nlm.nih.gov/pubmed/17991662</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">Lower RBC DHA/EPA levels associated with lower total brain volumes, greater white matter hyperintensity volumes, and lower scores on visual memory, executive function, and abstract thinking in a large (n=1575) subset of the Framingham cohort:<a href="https://www.ncbi.nlm.nih.gov/pubmed/22371413" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/22371413</a></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">Higher omega-3 intake associated with greater hippocampal, amygdalar, and total gray matter volume:<a href="https://www.ncbi.nlm.nih.gov/pubmed/17574755" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/17574755</a></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">Higher omega-3 serum levels partially offset the cognitive impairment of low physical activity:</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">https://www.ncbi.nlm.nih.gov/pubmed/24813150</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">Higher RBC EPA + DHA levels associated with less cognitive decline:</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">http://ajcn.nutrition.org/content/77/4/803.long</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p><p><strong>Human clinical trial</strong><p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">s:</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">DHA 1700 mg + EPA 600 mg did not slow/reverse cognitive decline in people with dementia over 6 months, but did slow decline in people with mild cognitive dysfunction with MMSE of 27 or greater:</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">https://www.ncbi.nlm.nih.gov/pubmed/17030655</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">EPA + DHA 1800 mg per day did not affect cognitive measures over 6 months in people with Alzheimer’s but did slow cognitive decline in people with mild cognitive impairment:</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">https://www.ncbi.nlm.nih.gov/pubmed/18573585</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">EPA + DHA 1800 mg per day did not impact cognition in people with MMSE scores of 21 or greater over 6 months:<a href="https://www.ncbi.nlm.nih.gov/pubmed/18678826" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/18678826</a></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">EPA 200 mg + DHA 500 mg had no effect on cognitive decline in older, cognitively healthy people over 2 years:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20410089" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/20410089</a></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">In a proprietary study, 900 mg DHA improved cognitive measures in people 55 years or greater over 6 months:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20434961" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/20434961</a></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'">DHA 2000 mg slowed cognitive decline in people with mild-moderate Alzheimer’s dementia but only in apo E3, not apo E4:Quinn JF. A clinical trial of docosahexaenoic acid (DHA) for the treatment of Alzheimer’s disease. Alzheimers Dementia. 2009;5(4) supplement: P84.</span></span></p> <p style="text-align: left"><span style="color: #000000"><span style="font-family: 'Verdana'"></span></span></p></blockquote><p></p>
[QUOTE="Vince, post: 96408, member: 843"] [LEFT][COLOR=#000000][FONT=Verdana]Higher fish consumption/omega-3 intake inversely associated with cognitive decline ages 45-70 years:[url]https://www.ncbi.nlm.nih.gov/pubmed/14745067[/url][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]Higher plasma omega-3 levels associated with less decline in selected measures of cognitive function (sensorimotor speed) but not in memory or word fluency over 3 years, ages 50-70:[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]https://www.ncbi.nlm.nih.gov/pubmed/17991662[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]Lower RBC DHA/EPA levels associated with lower total brain volumes, greater white matter hyperintensity volumes, and lower scores on visual memory, executive function, and abstract thinking in a large (n=1575) subset of the Framingham cohort:[url]https://www.ncbi.nlm.nih.gov/pubmed/22371413[/url][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]Higher omega-3 intake associated with greater hippocampal, amygdalar, and total gray matter volume:[url]https://www.ncbi.nlm.nih.gov/pubmed/17574755[/url][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]Higher omega-3 serum levels partially offset the cognitive impairment of low physical activity:[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]https://www.ncbi.nlm.nih.gov/pubmed/24813150[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]Higher RBC EPA + DHA levels associated with less cognitive decline:[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]http://ajcn.nutrition.org/content/77/4/803.long[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR][/LEFT][B]Human clinical trial[/B][LEFT][COLOR=#000000][FONT=Verdana]s:[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]DHA 1700 mg + EPA 600 mg did not slow/reverse cognitive decline in people with dementia over 6 months, but did slow decline in people with mild cognitive dysfunction with MMSE of 27 or greater:[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]https://www.ncbi.nlm.nih.gov/pubmed/17030655[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]EPA + DHA 1800 mg per day did not affect cognitive measures over 6 months in people with Alzheimer’s but did slow cognitive decline in people with mild cognitive impairment:[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]https://www.ncbi.nlm.nih.gov/pubmed/18573585[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]EPA + DHA 1800 mg per day did not impact cognition in people with MMSE scores of 21 or greater over 6 months:[url]https://www.ncbi.nlm.nih.gov/pubmed/18678826[/url][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]EPA 200 mg + DHA 500 mg had no effect on cognitive decline in older, cognitively healthy people over 2 years:[url]https://www.ncbi.nlm.nih.gov/pubmed/20410089[/url][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]In a proprietary study, 900 mg DHA improved cognitive measures in people 55 years or greater over 6 months:[url]https://www.ncbi.nlm.nih.gov/pubmed/20434961[/url][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR] [COLOR=#000000][FONT=Verdana]DHA 2000 mg slowed cognitive decline in people with mild-moderate Alzheimer’s dementia but only in apo E3, not apo E4:Quinn JF. A clinical trial of docosahexaenoic acid (DHA) for the treatment of Alzheimer’s disease. Alzheimers Dementia. 2009;5(4) supplement: P84.[/FONT][/COLOR] [COLOR=#000000][FONT=Verdana][/FONT][/COLOR][/LEFT] [/QUOTE]
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