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I have low SHBG and I like my E2 number to mirror my SHBG value. You stated E symptoms and you're still bothered by whatever you're feeling so push it a little lower. I don't think your numbers or dosing is otherwise troubling, keep it simple and just push your E2 a little lower. Ideally you want to time your bloods on Monday morning for your trough and then do your injection, since you're injecting once per week.