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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Stopping TRT protocol
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<blockquote data-quote="Cataceous" data-source="post: 219648" data-attributes="member: 38109"><p>Keep in mind that some guys quit TRT cold turkey without suffering too much. It's assumed that restart protocols can ease the transition, but I don't think there's much quantification of this. I think a more sensible protocol would have you taking hCG for some weeks prior to stopping the exogenous testosterone. Then when you stop the testosterone you would add a SERM, with enclomiphene being preferred. After a few weeks of hCG plus SERM you'd taper off the hCG, and then taper off the SERM. The problem with using hCG alone is that—depending on the dose—it can keep your HPTA suppressed, which then slows or stops the restart. I don't see much point in a washout period during which you don't take anything.</p><p></p><p>A restart protocol from Defy Medical a couple years ago goes like this:</p><ul> <li data-xf-list-type="ul">Discontinue testosterone</li> <li data-xf-list-type="ul">Start 300 IU hCG daily for 2 weeks</li> <li data-xf-list-type="ul">Stop hCG, start 25 mg enclomiphene daily for 6 weeks</li> <li data-xf-list-type="ul">0.125 mg anastrozole three times per week during both hCG and enclomiphene</li> <li data-xf-list-type="ul">Stop everything, followup labs with CBC, TT, FT E2, LH, SHBG, PRL</li> </ul><p>More of academic interest is the theoretical possibility of doing a complete HPTA restart before even stopping TRT. In this scenario, to the TRT protocol one would add doses of a SERM, kisspeptin-10, gonadorelin and hCG. After some period of time all of the medications would be tapered. The idea is that kisspeptin-10 encourages endogenous production of GnRH, while gonadorelin encourages production of LH and FSH. Meanwhile hCG is signaling the gonads to start producing testosterone. The SERM encourages the upstream activity by decreasing negative feedback from estrogens. This may also help to restart endogenous production of kisspeptin.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 219648, member: 38109"] Keep in mind that some guys quit TRT cold turkey without suffering too much. It's assumed that restart protocols can ease the transition, but I don't think there's much quantification of this. I think a more sensible protocol would have you taking hCG for some weeks prior to stopping the exogenous testosterone. Then when you stop the testosterone you would add a SERM, with enclomiphene being preferred. After a few weeks of hCG plus SERM you'd taper off the hCG, and then taper off the SERM. The problem with using hCG alone is that—depending on the dose—it can keep your HPTA suppressed, which then slows or stops the restart. I don't see much point in a washout period during which you don't take anything. A restart protocol from Defy Medical a couple years ago goes like this: [LIST] [*]Discontinue testosterone [*]Start 300 IU hCG daily for 2 weeks [*]Stop hCG, start 25 mg enclomiphene daily for 6 weeks [*]0.125 mg anastrozole three times per week during both hCG and enclomiphene [*]Stop everything, followup labs with CBC, TT, FT E2, LH, SHBG, PRL [/LIST] More of academic interest is the theoretical possibility of doing a complete HPTA restart before even stopping TRT. In this scenario, to the TRT protocol one would add doses of a SERM, kisspeptin-10, gonadorelin and hCG. After some period of time all of the medications would be tapered. The idea is that kisspeptin-10 encourages endogenous production of GnRH, while gonadorelin encourages production of LH and FSH. Meanwhile hCG is signaling the gonads to start producing testosterone. The SERM encourages the upstream activity by decreasing negative feedback from estrogens. This may also help to restart endogenous production of kisspeptin. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Stopping TRT protocol
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