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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Stopping Testosterone Injections for Enclomiphene
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<blockquote data-quote="Cataceous" data-source="post: 188553" data-attributes="member: 38109"><p>In the experiment GnRH is used in place of hCG. GnRH acts at the pituitary to stimulate production of LH and FSH. However, at the pituitary there is negative feedback from estrogens, which reduces its responsiveness to GnRH. What I don't know is the relative strength of this negative feedback. In a normal HPTA there is also negative feedback at the hypothalamus from both androgens and estrogens. The three types of negative feedback act to regulate our testosterone. Given that by using exogenous GnRH we bypass negative feedback at the hypothalamus, it's possible that a greater amount of exogenous testosterone may be tolerated before suppression at the pituitary becomes significant. So to answer your question, a low enough TRT dose is probably that which would give you serum testosterone levels comparable to what you'd have if your HPTA were functioning properly. And even a higher dose may work if the suppressive action at the pituitary is small relative to that at the hypothalamus.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 188553, member: 38109"] In the experiment GnRH is used in place of hCG. GnRH acts at the pituitary to stimulate production of LH and FSH. However, at the pituitary there is negative feedback from estrogens, which reduces its responsiveness to GnRH. What I don't know is the relative strength of this negative feedback. In a normal HPTA there is also negative feedback at the hypothalamus from both androgens and estrogens. The three types of negative feedback act to regulate our testosterone. Given that by using exogenous GnRH we bypass negative feedback at the hypothalamus, it's possible that a greater amount of exogenous testosterone may be tolerated before suppression at the pituitary becomes significant. So to answer your question, a low enough TRT dose is probably that which would give you serum testosterone levels comparable to what you'd have if your HPTA were functioning properly. And even a higher dose may work if the suppressive action at the pituitary is small relative to that at the hypothalamus. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Stopping Testosterone Injections for Enclomiphene
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