The biggest problem with both clomiphene and enclomiphene is that there is no proof of actual symptomatic benefit and that is why neither FDA nor the European agency EMA approved it. This is not some "conspiracy of Big Pharma" but elementary medical logic - they want demonstration of improvement not pointless increases in some lab values.
It is flat out suspicious to me that the maker of enclomiphene Repros did an elaborate study, measured it increased testosterone and then BAM no measurement of the actual improvement of sexual, physical, or psychological functioning. I wonder why .....
At the bottom I attached one "study" for the effectiveness of clomiphene:
Testosterone Supplementation Versus Clomiphene Citrate: An Age Matched Comparison Of Satisfaction And Efficacy
[ATTACH=full]10826[/ATTACH]
On their main graph above, there is NO difference in hypogonadal symptoms (the blue bars), measured by qADAM questionnaire (higher values = less symptoms), between hypogonadal men (age ~ 40) after being treated with testosterone, clomiphene (25mg/day), or NOT treated at all (Controls)!!! That was interpreted as 'clomiphene is as good as testosterone', when the correct conclusion from their graph is 'clomiphene is as good as nothing' LOL Of course the problem is first that the men considered were relatively young and did not have severe hypogonadal symptoms, and the second problem is qADAM because clearly it is not a good questionnaire - it gives same values for all groups, which invalidates the whole plain stupid 'study'.
