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Stop taking Vitamin D already
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<blockquote data-quote="BigTex" data-source="post: 230014" data-attributes="member: 43589"><p>@ Systemlord....I am curious, why were you taking 18,000 IU of vitamin D3? </p><p></p><p>Here is another rather interesting study:</p><p></p><p>Hossein-nezhad A, Spira A, Holick MF. <strong>Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. </strong>PLoS One. 2013;8(3):e58725. doi: 10.1371/journal.pone.0058725. Epub 2013 Mar 20. PMID: 23527013; PMCID: PMC3604145.</p><p></p><h3>Conclusion/Significance</h3><p>Our data suggest that any improvement in vitamin D status will significantly affect expression of genes that have a wide variety of biologic functions of more than 160 pathways linked to cancer, autoimmune disorders and cardiovascular disease with have been associated with vitamin D deficiency. This study reveals for the first time molecular finger prints that help explain the nonskeletal health benefits of vitamin D.</p><p></p><p>Now, I do see a lot of thing D3 does touted that have been show to not be so true.</p><p></p><p>Montenegro KR, Cruzat V, Melder H, Jacques A, Newsholme P, Ducker KJ. <strong>Vitamin D Supplementation Does Not Impact Resting Metabolic Rate, Body Composition and Strength in Vitamin D Sufficient Physically Active Adults. </strong>Nutrients. 2020 Oct 12;12(10):3111. doi: 10.3390/nu12103111. PMID: 33053823; PMCID: PMC7601703.</p><p></p><p><strong>Abstract and figures</strong></p><p>Supplementation with the most efficient form of Vitamin D (VitD3) results in improvements in energy metabolism, muscle mass and strength in VitD deficient individuals. Whether similar outcomes occur in VitD sufficient individuals' remains to be elucidated. The aim of this study is to determine the effect of VitD3 supplementation on resting metabolic rate (RMR), body composition and strength in VitD sufficient physically active young adults. Participants completed pre-supplementation testing before being matched for sunlight exposure and randomly allocated in a counterbalanced manner to the VitD3 or placebo group. Following 12 weeks of 50 IU/kg body-mass VitD3 supplementation, participants repeated the pre-supplementation testing. Thirty-one adults completed the study (19 females and 12 males; mean ± standard deviation (SD); age = 26.6 ± 4.9 years; BMI = 24.2 ± 4.1 kg·m 2). The VitD group increased serum total 25(OH)D by 30 nmol/L while the placebo group decreased total serum concentration by 21 nmol/L, reaching 123 (51) and 53 (42.2) nmol/L, respectively. <strong>There were no significant changes in muscle strength or power, resting metabolic rate and body composition over the 12-week period. </strong>Physically active young adults that are VitD sufficient have demonstrated that no additional physiological effects of achieving supraphysiological serum total 25(OH)D concentrations after VitD3 supplementation.</p><p></p><p>OK, this was in physically active adults. How about elite level athletes, do we get the same results?</p><p></p><p>Alimoradi K, Nikooyeh B, Ravasi AA, Zahedirad M, Shariatzadeh N, Kalayi A, Neyestani TR. <strong>Efficacy of Vitamin D Supplementation in Physical Performance of Iranian Elite Athletes.</strong> Int J Prev Med. 2019 Jun 7;10:100. doi: 10.4103/ijpvm.IJPVM_227_18. PMID: 31360347; PMCID: PMC6592128.</p><p></p><h2>Abstract</h2><p><strong>Background: </strong>There has been no report of the vitamin D status of the professional athletes from Iran to date. This study was performed to evaluate the efficacy of weekly vitamin D supplementation on athletic performance in Iranian athletes expedited to Asian competition in Taipei, China, 2015.</p><p><strong>Methods: </strong>This study was a randomized controlled clinical trial. Seventy subjects were enrolled in the study. The athletes were randomly divided into two groups: vitamin D supplement (D; received 50,000 IU of vitamin D supplement weekly) and control (P, received a placebo weekly). Duration of the study was 8 weeks. Anthropometric, dietary, athletic performance, and biochemical evaluations were performed for all subjects in the beginning and in the end of the intervention period.</p><p><strong>Results: </strong>A significant rise in circulating 25(OH)D concentration was observed in D group (17.3 ± 16.9 ng/mL, <em>P</em> < 0.001), whereas in <em>P</em> group, there was a statistically significant decrement (-3.1 ± 8.4 ng/mL, <em>P</em> = 0.040). There were no either within- or between-group significant differences in Ergo jump, vertical jump, and agility tests. In strength leg press tests, both groups showed a significant improvement. However, comparisons of changes revealed that the improvement in D group was significantly higher than in <em>P</em> group (<em>P</em> = 0.034). Moreover, in sprint test (one repetition-Max, 1RM), only D group had a significant within-group improvement (<em>P</em> = 0.030).</p><p><strong>Conclusions: </strong>Weekly supplementation with 50,000 IU vitamin D resulted in nearly 17 ng/mL increment in circulating calcidiol. This increase was associated with significant improvement of power leg press and sprint tests in D-supplemented group.</p><p></p><p>WOW! 50,000IU? Makes Systemlord's dose look very small. However the hyper-supplementation seemed to affect power and speed in elite athletes. Interesting.</p></blockquote><p></p>
[QUOTE="BigTex, post: 230014, member: 43589"] @ Systemlord....I am curious, why were you taking 18,000 IU of vitamin D3? Here is another rather interesting study: Hossein-nezhad A, Spira A, Holick MF. [B]Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. [/B]PLoS One. 2013;8(3):e58725. doi: 10.1371/journal.pone.0058725. Epub 2013 Mar 20. PMID: 23527013; PMCID: PMC3604145. [HEADING=2]Conclusion/Significance[/HEADING] Our data suggest that any improvement in vitamin D status will significantly affect expression of genes that have a wide variety of biologic functions of more than 160 pathways linked to cancer, autoimmune disorders and cardiovascular disease with have been associated with vitamin D deficiency. This study reveals for the first time molecular finger prints that help explain the nonskeletal health benefits of vitamin D. Now, I do see a lot of thing D3 does touted that have been show to not be so true. Montenegro KR, Cruzat V, Melder H, Jacques A, Newsholme P, Ducker KJ. [B]Vitamin D Supplementation Does Not Impact Resting Metabolic Rate, Body Composition and Strength in Vitamin D Sufficient Physically Active Adults. [/B]Nutrients. 2020 Oct 12;12(10):3111. doi: 10.3390/nu12103111. PMID: 33053823; PMCID: PMC7601703. [B]Abstract and figures[/B] Supplementation with the most efficient form of Vitamin D (VitD3) results in improvements in energy metabolism, muscle mass and strength in VitD deficient individuals. Whether similar outcomes occur in VitD sufficient individuals' remains to be elucidated. The aim of this study is to determine the effect of VitD3 supplementation on resting metabolic rate (RMR), body composition and strength in VitD sufficient physically active young adults. Participants completed pre-supplementation testing before being matched for sunlight exposure and randomly allocated in a counterbalanced manner to the VitD3 or placebo group. Following 12 weeks of 50 IU/kg body-mass VitD3 supplementation, participants repeated the pre-supplementation testing. Thirty-one adults completed the study (19 females and 12 males; mean ± standard deviation (SD); age = 26.6 ± 4.9 years; BMI = 24.2 ± 4.1 kg·m 2). The VitD group increased serum total 25(OH)D by 30 nmol/L while the placebo group decreased total serum concentration by 21 nmol/L, reaching 123 (51) and 53 (42.2) nmol/L, respectively. [B]There were no significant changes in muscle strength or power, resting metabolic rate and body composition over the 12-week period. [/B]Physically active young adults that are VitD sufficient have demonstrated that no additional physiological effects of achieving supraphysiological serum total 25(OH)D concentrations after VitD3 supplementation. OK, this was in physically active adults. How about elite level athletes, do we get the same results? Alimoradi K, Nikooyeh B, Ravasi AA, Zahedirad M, Shariatzadeh N, Kalayi A, Neyestani TR. [B]Efficacy of Vitamin D Supplementation in Physical Performance of Iranian Elite Athletes.[/B] Int J Prev Med. 2019 Jun 7;10:100. doi: 10.4103/ijpvm.IJPVM_227_18. PMID: 31360347; PMCID: PMC6592128. [HEADING=1]Abstract[/HEADING] [B]Background: [/B]There has been no report of the vitamin D status of the professional athletes from Iran to date. This study was performed to evaluate the efficacy of weekly vitamin D supplementation on athletic performance in Iranian athletes expedited to Asian competition in Taipei, China, 2015. [B]Methods: [/B]This study was a randomized controlled clinical trial. Seventy subjects were enrolled in the study. The athletes were randomly divided into two groups: vitamin D supplement (D; received 50,000 IU of vitamin D supplement weekly) and control (P, received a placebo weekly). Duration of the study was 8 weeks. Anthropometric, dietary, athletic performance, and biochemical evaluations were performed for all subjects in the beginning and in the end of the intervention period. [B]Results: [/B]A significant rise in circulating 25(OH)D concentration was observed in D group (17.3 ± 16.9 ng/mL, [I]P[/I] < 0.001), whereas in [I]P[/I] group, there was a statistically significant decrement (-3.1 ± 8.4 ng/mL, [I]P[/I] = 0.040). There were no either within- or between-group significant differences in Ergo jump, vertical jump, and agility tests. In strength leg press tests, both groups showed a significant improvement. However, comparisons of changes revealed that the improvement in D group was significantly higher than in [I]P[/I] group ([I]P[/I] = 0.034). Moreover, in sprint test (one repetition-Max, 1RM), only D group had a significant within-group improvement ([I]P[/I] = 0.030). [B]Conclusions: [/B]Weekly supplementation with 50,000 IU vitamin D resulted in nearly 17 ng/mL increment in circulating calcidiol. This increase was associated with significant improvement of power leg press and sprint tests in D-supplemented group. WOW! 50,000IU? Makes Systemlord's dose look very small. However the hyper-supplementation seemed to affect power and speed in elite athletes. Interesting. [/QUOTE]
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