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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Steroids for burn trauma
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<blockquote data-quote="madman" data-source="post: 160349" data-attributes="member: 13851"><p><strong>Oxandrolone in the treatment of burn injuries: <span style="color: rgb(184, 49, 47)">A systematic review and meta-analysis </span></strong></p><p></p><p></p><p><strong>Abstract Background:</strong> <span style="color: rgb(184, 49, 47)">Severe burns induce a profound hypermetabolic response, leading to a prolonged state of catabolism associated with organ dysfunction and delay of wound healing. </span><span style="color: rgb(44, 130, 201)"><strong>Oxandrolone, a synthetic testosterone analog, may alleviate the hypermetabolic catabolic state thereby decreasing associated morbidity. However, current literature has reported mixed outcomes on complications following Oxandrolone use, specifically liver and lung function. </strong></span><span style="color: rgb(26, 188, 156)"><strong>We conducted an updated systematic review and meta-analysis studying the effects of Oxandrolone on mortality, length of hospital stay, progressive liver dysfunction, and nine secondary outcomes. </strong></span></p><p></p><p><strong>Methods:</strong> We searched Pubmed, EMBASE, Web of Science, CINAHL, and Cochrane Databases of Systematic Reviews and Randomized Controlled Trials. <span style="color: rgb(184, 49, 47)">31 Randomized control trials and observational studies were included.</span> Basic science and animal studies were excluded. Only studies comparing Oxandrolone to standard of care, or placebo, were included.</p><p></p><p><strong>Results: </strong><span style="color: rgb(184, 49, 47)">Oxandrolone did not affect rates of mortality (RR:0.72; 95% CI(0.47-1.08);p=0.11) or progressive liver dysfunction (RR:1.04; 95% CI(0.59-1.85);p=0.88), but did decrease length of stay in-hospital.</span> <span style="color: rgb(44, 130, 201)"><strong>Oxandrolone significantly increased weight re-gain, bone mineral density, percent lean body mass, and decreased wound healing time for donor graft sites.</strong></span> <span style="color: rgb(26, 188, 156)"><strong>Oxandrolone did not change the incidence of transient liver dysfunction or mechanical ventilation requirements. </strong></span></p><p></p><p><strong>Conclusions:</strong> <span style="color: rgb(44, 130, 201)"><strong>There is evidence to suggest that Oxandrolone is a beneficial adjunct to the acute care of burn patients; shortening hospital stays and improving several growth and wound healing parameters.</strong></span> <span style="color: rgb(26, 188, 156)"><strong>It does not appear that Oxandrolone increases the risk of progressive or transient liver injury, although monitoring liver enzymes is recommended. </strong></span></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusions</strong></p><p><span style="color: rgb(184, 49, 47)"><strong>There is evidence to suggest that the addition of Oxandrolone to standard treatment for burn patients decreases length of stay in hospital by accelerating wound healing, but does not appear to affect mortality rates.</strong></span> <span style="color: rgb(26, 188, 156)"><strong>Although the definition of liver dysfunction was not consistent among the studies included, and we recommend continued monitoring of liver enzymes levels in patients receiving Oxandrolone, we did not find evidence of increased risk of transient or progressive liver dysfunction. </strong></span><span style="color: rgb(44, 130, 201)"><strong>Following burn injury, Oxandrolone appears to significantly increase weight gain, accelerate wound healing for skin graft donor sites, and improve body composition.</strong></span><span style="color: rgb(147, 101, 184)"><strong> We found that children did not experience increased morbidity or mortality when compared adults given Oxandrolone, and may additionally benefit from improved bone mineral density. </strong></span><span style="color: rgb(0, 0, 0)"><strong>Therefore, we suggest that Oxandrolone is a safe adjunct in the treatment of severely burned patients. </strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 160349, member: 13851"] [B]Oxandrolone in the treatment of burn injuries: [COLOR=rgb(184, 49, 47)]A systematic review and meta-analysis [/COLOR][/B] [B]Abstract Background:[/B] [COLOR=rgb(184, 49, 47)]Severe burns induce a profound hypermetabolic response, leading to a prolonged state of catabolism associated with organ dysfunction and delay of wound healing. [/COLOR][COLOR=rgb(44, 130, 201)][B]Oxandrolone, a synthetic testosterone analog, may alleviate the hypermetabolic catabolic state thereby decreasing associated morbidity. However, current literature has reported mixed outcomes on complications following Oxandrolone use, specifically liver and lung function. [/B][/COLOR][COLOR=rgb(26, 188, 156)][B]We conducted an updated systematic review and meta-analysis studying the effects of Oxandrolone on mortality, length of hospital stay, progressive liver dysfunction, and nine secondary outcomes. [/B][/COLOR] [B]Methods:[/B] We searched Pubmed, EMBASE, Web of Science, CINAHL, and Cochrane Databases of Systematic Reviews and Randomized Controlled Trials. [COLOR=rgb(184, 49, 47)]31 Randomized control trials and observational studies were included.[/COLOR] Basic science and animal studies were excluded. Only studies comparing Oxandrolone to standard of care, or placebo, were included. [B]Results: [/B][COLOR=rgb(184, 49, 47)]Oxandrolone did not affect rates of mortality (RR:0.72; 95% CI(0.47-1.08);p=0.11) or progressive liver dysfunction (RR:1.04; 95% CI(0.59-1.85);p=0.88), but did decrease length of stay in-hospital.[/COLOR] [COLOR=rgb(44, 130, 201)][B]Oxandrolone significantly increased weight re-gain, bone mineral density, percent lean body mass, and decreased wound healing time for donor graft sites.[/B][/COLOR] [COLOR=rgb(26, 188, 156)][B]Oxandrolone did not change the incidence of transient liver dysfunction or mechanical ventilation requirements. [/B][/COLOR] [B]Conclusions:[/B] [COLOR=rgb(44, 130, 201)][B]There is evidence to suggest that Oxandrolone is a beneficial adjunct to the acute care of burn patients; shortening hospital stays and improving several growth and wound healing parameters.[/B][/COLOR] [COLOR=rgb(26, 188, 156)][B]It does not appear that Oxandrolone increases the risk of progressive or transient liver injury, although monitoring liver enzymes is recommended. [/B][/COLOR] [B]Conclusions[/B] [COLOR=rgb(184, 49, 47)][B]There is evidence to suggest that the addition of Oxandrolone to standard treatment for burn patients decreases length of stay in hospital by accelerating wound healing, but does not appear to affect mortality rates.[/B][/COLOR] [COLOR=rgb(26, 188, 156)][B]Although the definition of liver dysfunction was not consistent among the studies included, and we recommend continued monitoring of liver enzymes levels in patients receiving Oxandrolone, we did not find evidence of increased risk of transient or progressive liver dysfunction. [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]Following burn injury, Oxandrolone appears to significantly increase weight gain, accelerate wound healing for skin graft donor sites, and improve body composition.[/B][/COLOR][COLOR=rgb(147, 101, 184)][B] We found that children did not experience increased morbidity or mortality when compared adults given Oxandrolone, and may additionally benefit from improved bone mineral density. [/B][/COLOR][COLOR=rgb(0, 0, 0)][B]Therefore, we suggest that Oxandrolone is a safe adjunct in the treatment of severely burned patients. [/B][/COLOR] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Steroids for burn trauma
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