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I would say on average 100-150mg/week would get many into the upper end of the physiological range which for the experienced trt doctors would be acceptable and a smaller percentage may need 200mg/week but it is not common. Most inexperienced gps would prefer to have patients mid-normal so 200mg every 2 weeks would be more commonly prescribed. I would say when one starts injecting more than 200mg/week there is definitely a negative impact on lipids/worsening of hematocrit/hemoglobin and increased chance of sides related to e2 (water retention/increased blood pressure/gyno) and dht (bph/acne/hair loss) but ones genetics would play a big role especially regarding gyno/hair loss/acne. The body prefers equilibrium and anything in excess would not be healthy!