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General Health & Fitness
Health & Wellness
Statins and Muscle Performance: Evidence for Metabolism Disturbance
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<blockquote data-quote="CoastWatcher" data-source="post: 84916" data-attributes="member: 2624"><p>It's well established that statins, prescribed to treat elevated cholesterol, can cause muscular myopathy: myalgia, myositis, and - most significantly - rhabdomyolysis. A study recently tried to determine if differences in exercise performance, muscle function, and mitochondrial oxidative capacity existed between symptomatic stain users (those reporting some degree of muscle pain), asymptomatic statin users, and a control group. The study was small, ten participants were enrolled in each group, and maximal incremental cycling tests along with involuntary, electrically stimulated isometric quadriceps muscle contractions were performed and muscle biopsies were obtained from the vastus lateralis muscle.</p><p></p><ul> <li data-xf-list-type="ul">VO2 peak, maximal work load, and ventilatory efficiency were comparable between groups.</li> <li data-xf-list-type="ul">Both statin groups had a depressed anaerobic threshold compared to controls.</li> <li data-xf-list-type="ul">Muscle fatigability revealed a prolonged relaxation time in both statin groups as compared to the controls.</li> <li data-xf-list-type="ul">Mitochondrial activity of complexes (C) II and IV was lower in symptomatic statin users.</li> <li data-xf-list-type="ul">Mitochondrial content was lower in both statin groups than controls.</li> </ul><p></p><p>Statin use attenuates substrate during maximal exercise performance, induces muscle fatigue during repeated muscle contractions, and decreases mitochondrial oxidative capacity of the muscle. Disturbances in mitochondrial capacity occur with statin use even in those patients without statin-induced muscle complaints.</p><p></p><p>"Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism," <em>The Journal of Clinical Endocrinology and Metabolism, </em>9 October 2017</p><p></p><p><a href="https://academic.oup.com/jcem/article-abstract/doi/10.1210/jc.2017-01561/4364961/Statins-affect-skeletal-muscle-performance?redirectedFrom=fulltext" target="_blank">https://academic.oup.com/jcem/article-abstract/doi/10.1210/jc.2017-01561/4364961/Statins-affect-skeletal-muscle-performance?redirectedFrom=fulltext</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 84916, member: 2624"] It's well established that statins, prescribed to treat elevated cholesterol, can cause muscular myopathy: myalgia, myositis, and - most significantly - rhabdomyolysis. A study recently tried to determine if differences in exercise performance, muscle function, and mitochondrial oxidative capacity existed between symptomatic stain users (those reporting some degree of muscle pain), asymptomatic statin users, and a control group. The study was small, ten participants were enrolled in each group, and maximal incremental cycling tests along with involuntary, electrically stimulated isometric quadriceps muscle contractions were performed and muscle biopsies were obtained from the vastus lateralis muscle. [LIST] [*]VO2 peak, maximal work load, and ventilatory efficiency were comparable between groups. [*]Both statin groups had a depressed anaerobic threshold compared to controls. [*]Muscle fatigability revealed a prolonged relaxation time in both statin groups as compared to the controls. [*]Mitochondrial activity of complexes (C) II and IV was lower in symptomatic statin users. [*]Mitochondrial content was lower in both statin groups than controls. [/LIST] Statin use attenuates substrate during maximal exercise performance, induces muscle fatigue during repeated muscle contractions, and decreases mitochondrial oxidative capacity of the muscle. Disturbances in mitochondrial capacity occur with statin use even in those patients without statin-induced muscle complaints. "Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism," [I]The Journal of Clinical Endocrinology and Metabolism, [/I]9 October 2017 [URL]https://academic.oup.com/jcem/article-abstract/doi/10.1210/jc.2017-01561/4364961/Statins-affect-skeletal-muscle-performance?redirectedFrom=fulltext[/URL] [/QUOTE]
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Statins and Muscle Performance: Evidence for Metabolism Disturbance
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