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Allow me to offer an even more conservative perspective. That 100 mg per week of testosterone cypionate would already be giving you more testosterone than most men ever make naturally. The average testosterone production for healthy young men is equivalent to around 60-70 mg of testosterone cypionate per week. This is a safer starting point for TRT as long as it's in divided doses. Although a lot of men seem to tolerate supraphysiological doses, many experience side effects and regret starting higher rather than adopting a true low-and-slow approach. I have collected some of these anecdotes here:

[EMBED content="post-245316"]https://www.excelmale.com/threads/answering-some-questions-new-to-forum-much-appreciated.26955/#post-245316[/EMBED]

If your goal is overall good health then I suggest you tell your consultant at Defy that you would prefer to start with doses in the physiological range. If you do this then you will at least have a baseline to compare against should you want to try higher doses later on.


By the way, I have been with Defy for 10 years and they have no objections to use of lower doses, e.g. equivalent to ~40 mg TC/week in my case. You just have to ask.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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