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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Starting to question my therapy
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<blockquote data-quote="Nelson Vergel" data-source="post: 111704" data-attributes="member: 3"><p>You may not be reaching enough REM sleep.</p><p></p><p>Here is a study:</p><p></p><p><strong>DECREASE OF NOCTURNAL PENILE TUMESCENCE DUE TO REM SLEEP</strong></p><p><strong>DEPRIVATION IN YOUNG HEALTHY MALES: YOUNG,</strong></p><p><strong>HEALTHY...IMPOTENT?</strong></p><p></p><p>Kamp S., Ott R., Hatzinger M., Knoll T., Juenemann K.P., Alken P., Bross S.</p><p>University Hospital, Department of Urology, Mannheim, Germany</p><p></p><p>INTRODUCTION & OBJECTIVES: To determine the influence of a</p><p>disturbance of the physiological sleep pattern on Nocturnal Penile Tumescences</p><p>(NPT) in young healthy males and to evaluate the significance of NPT measurement</p><p>for the diagnostic of erectile dysfunction under in patient-conditions.</p><p></p><p>MATERIAL & METHODS: 10 healthy young males, mean age 25.2 years (25-</p><p>32) were examined on 3 nights under sleep laboratory conditions. A 12-channel polysomnography was performed to register the sleep stages, NPT were</p><p>continuously measured with the RigiScan-device in all three nights. In night 2</p><p>we performed additional measurement of vital parameters as heart rate and blood</p><p>pressure. In night 3, in addition, sleep was interrupted and blood was drawn via an</p><p>i.v.-line every two hours to determine the serum levels of testosterone, FAI (free</p><p>androgen index), estradiol, LH, FSH, prolactin, DHEA-S, and SHBG.</p><p></p><p>RESULTS: We found a significant decrease of REM-sleep in night 3 versus night</p><p>1 (8 vs. 17%, p>O.O5) and a significant reduction of the total time length</p><p>of erections (50.2 vs. 98.8 min, p>O.O3). Phase 3 and 4 sleep was also decreased,</p><p>whereas Sl and S2 sleep was increased. The total number of events was</p><p>significantly decreased in night 3 (3.7 vs. 5.5, p>O.O5). The amount of NPT</p><p>correlated to REM-sleep decreased from 80% in night 1 to 53% in night 3</p><p>(p>O.O3). There was no disturbance of the circadian rhythm and pulsatile</p><p>secretion of the measured sexual hormones in this study.</p><p></p><p>CONCLUSIONS: The disturbance of the physiological sleep pattern leads to a</p><p>significant reduction of REM and S3/4 sleep combined with a significant decrease</p><p>in the number and total length of nocturnal erections in young healthy adults, with</p><p>some showing the pattern similar to patients with erectile dysfunction. Therefore, a</p><p>normal sleep pattern is crucial for the evaluation of NPT-measurements in the</p><p>diagnostics of erectile dysfunction and a combination with polysomnography should</p><p>be performed to exclude the diagnosis of erectile dysfunction in healthy men.</p><p></p><p>_______________________________</p><p></p><p></p><p><strong>Defining association between sleep apnea syndrome and erectile dysfunction</strong></p><p></p><p></p><p>Abstract</p><p></p><p>Objectives</p><p>To conduct a study using validated sexual function and sleepiness inventories to define whether sleep apnea syndrome (SAS) is associated with erectile dysfunction and whether any correlation exists between the severity of SAS and the severity of erectile dysfunction. Previous work has suggested that sleep disorders are associated with erectile dysfunction.</p><p></p><p>Methods</p><p>Men presenting to a sleep clinic with symptoms consistent with SAS were given the Epworth Sleepiness Scale and an erectile dysfunction risk factor inventory, the International Index of Erectile Function. A database was constructed and statistical analysis conducted to define the correlation between the two entities.</p><p></p><p>Results</p><p>A total of 50 men met the criteria for inclusion. Of the 50 men, 60% had abnormal Epworth Sleepiness Scale scores and 80% of these patients had erectile dysfunction as determined by inventory scores compared with 20% of the men with normal Epworth Sleepiness Scale scores. There were statistically significant differences between men with normal and abnormal sleepiness scores for the total and erectile function domain of the International Index of Erectile Function. The correlation between the severity of the sleepiness and the severity of erectile dysfunction was good (r = &#8722;0.80, P = 0.012).</p><p></p><p>Conclusions</p><p>Men presenting with symptoms consistent with SAS have a significant risk of erectile dysfunction, and the correlation between the severity of sleep apnea and the severity of erectile dysfunction is strong.</p><p></p><p></p><p>Reference: Urology. Volume 67, Issue 5, May 2006, Pages 1033-1037</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 111704, member: 3"] You may not be reaching enough REM sleep. Here is a study: [B]DECREASE OF NOCTURNAL PENILE TUMESCENCE DUE TO REM SLEEP DEPRIVATION IN YOUNG HEALTHY MALES: YOUNG, HEALTHY...IMPOTENT?[/B] Kamp S., Ott R., Hatzinger M., Knoll T., Juenemann K.P., Alken P., Bross S. University Hospital, Department of Urology, Mannheim, Germany INTRODUCTION & OBJECTIVES: To determine the influence of a disturbance of the physiological sleep pattern on Nocturnal Penile Tumescences (NPT) in young healthy males and to evaluate the significance of NPT measurement for the diagnostic of erectile dysfunction under in patient-conditions. MATERIAL & METHODS: 10 healthy young males, mean age 25.2 years (25- 32) were examined on 3 nights under sleep laboratory conditions. A 12-channel polysomnography was performed to register the sleep stages, NPT were continuously measured with the RigiScan-device in all three nights. In night 2 we performed additional measurement of vital parameters as heart rate and blood pressure. In night 3, in addition, sleep was interrupted and blood was drawn via an i.v.-line every two hours to determine the serum levels of testosterone, FAI (free androgen index), estradiol, LH, FSH, prolactin, DHEA-S, and SHBG. RESULTS: We found a significant decrease of REM-sleep in night 3 versus night 1 (8 vs. 17%, p>O.O5) and a significant reduction of the total time length of erections (50.2 vs. 98.8 min, p>O.O3). Phase 3 and 4 sleep was also decreased, whereas Sl and S2 sleep was increased. The total number of events was significantly decreased in night 3 (3.7 vs. 5.5, p>O.O5). The amount of NPT correlated to REM-sleep decreased from 80% in night 1 to 53% in night 3 (p>O.O3). There was no disturbance of the circadian rhythm and pulsatile secretion of the measured sexual hormones in this study. CONCLUSIONS: The disturbance of the physiological sleep pattern leads to a significant reduction of REM and S3/4 sleep combined with a significant decrease in the number and total length of nocturnal erections in young healthy adults, with some showing the pattern similar to patients with erectile dysfunction. Therefore, a normal sleep pattern is crucial for the evaluation of NPT-measurements in the diagnostics of erectile dysfunction and a combination with polysomnography should be performed to exclude the diagnosis of erectile dysfunction in healthy men. _______________________________ [B]Defining association between sleep apnea syndrome and erectile dysfunction[/B] Abstract Objectives To conduct a study using validated sexual function and sleepiness inventories to define whether sleep apnea syndrome (SAS) is associated with erectile dysfunction and whether any correlation exists between the severity of SAS and the severity of erectile dysfunction. Previous work has suggested that sleep disorders are associated with erectile dysfunction. Methods Men presenting to a sleep clinic with symptoms consistent with SAS were given the Epworth Sleepiness Scale and an erectile dysfunction risk factor inventory, the International Index of Erectile Function. A database was constructed and statistical analysis conducted to define the correlation between the two entities. Results A total of 50 men met the criteria for inclusion. Of the 50 men, 60% had abnormal Epworth Sleepiness Scale scores and 80% of these patients had erectile dysfunction as determined by inventory scores compared with 20% of the men with normal Epworth Sleepiness Scale scores. There were statistically significant differences between men with normal and abnormal sleepiness scores for the total and erectile function domain of the International Index of Erectile Function. The correlation between the severity of the sleepiness and the severity of erectile dysfunction was good (r = −0.80, P = 0.012). Conclusions Men presenting with symptoms consistent with SAS have a significant risk of erectile dysfunction, and the correlation between the severity of sleep apnea and the severity of erectile dysfunction is strong. Reference: Urology. Volume 67, Issue 5, May 2006, Pages 1033-1037 [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Starting to question my therapy
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