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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Started TRT .... Looking forward (updated w 8/20/18 Labs)
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<blockquote data-quote="madman" data-source="post: 110923" data-attributes="member: 13851"><p>Endogenous testosterone production: diurnal rhythm (24hr)-episodic fluctuation in circulating testosterone levels over shorter periods (minutes to hours) carried along by pulsatile lh secretion.</p><p></p><p>Diurnal patterns of morning peak testosterone levels and nadir levels in the mid afternoon are evident in YOUNGER and healthy OLDER men hence it is conventional practice to STANDARDIZE testosterone measurements to morning blood samples on at least 2 different days.</p><p></p><p>Regarding exogenous t patches and trandermal (gel/cream) would be a close as one could get to mimicking the natural diurnal rhythm as oppose to injectables which in no way mimic the natural diurnal rhythm even when injecting daily.</p><p></p><p>When one uses transdermal and reaches steady state blood work for testosterone levels is done within 2hrs after application (peak).</p><p></p><p></p><p>Exogenous testosterone: steady state (depot testosterone injections maintain steady state delivery pattern depending on dose/injection frequency/ester used/ones shbg levels)</p><p></p><p>Regarding peak/trough ones dose, injection frequency, ester used and of course ones shbg levels are all contributing factors.</p><p></p><p>When one is injecting once weekly (higher doses) there is a big difference between peak/trough and stability of testosterone levels as oppose to injecting more frequently using lower doses.</p><p></p><p>Injecting every 3.5 days or M/W/F would result in a lesser peak/trough and more stable blood levels and when injecting EOD or daily peaks/troughs would be greatly minimized and steadier blood levels would be achieve.</p><p></p><p>Are we comparing natural endogenous testosterone (24hr diurnal rhythm) to exogenous testosterone injections resulting in steady state as in levels elevated over a period of days?</p></blockquote><p></p>
[QUOTE="madman, post: 110923, member: 13851"] Endogenous testosterone production: diurnal rhythm (24hr)-episodic fluctuation in circulating testosterone levels over shorter periods (minutes to hours) carried along by pulsatile lh secretion. Diurnal patterns of morning peak testosterone levels and nadir levels in the mid afternoon are evident in YOUNGER and healthy OLDER men hence it is conventional practice to STANDARDIZE testosterone measurements to morning blood samples on at least 2 different days. Regarding exogenous t patches and trandermal (gel/cream) would be a close as one could get to mimicking the natural diurnal rhythm as oppose to injectables which in no way mimic the natural diurnal rhythm even when injecting daily. When one uses transdermal and reaches steady state blood work for testosterone levels is done within 2hrs after application (peak). Exogenous testosterone: steady state (depot testosterone injections maintain steady state delivery pattern depending on dose/injection frequency/ester used/ones shbg levels) Regarding peak/trough ones dose, injection frequency, ester used and of course ones shbg levels are all contributing factors. When one is injecting once weekly (higher doses) there is a big difference between peak/trough and stability of testosterone levels as oppose to injecting more frequently using lower doses. Injecting every 3.5 days or M/W/F would result in a lesser peak/trough and more stable blood levels and when injecting EOD or daily peaks/troughs would be greatly minimized and steadier blood levels would be achieve. Are we comparing natural endogenous testosterone (24hr diurnal rhythm) to exogenous testosterone injections resulting in steady state as in levels elevated over a period of days? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Started TRT .... Looking forward (updated w 8/20/18 Labs)
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