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Thanks for all the responses, guys.

So my Estradiol (NOT using sensitive method) went from 20.5 to 34.9 [7.6 - 42.6] in the month+ of my TRT regimen. I didn't say anything to the T clinic when they gave me the anastrazole. I'm just not going to take it (also, the clinician wrongly told me the upper range was 35 when he was talking about the jump my estradiol made). I have a consult with Defy on Wednesday.

I'm fine with having a need to take an AI. But without symptoms, and without levels that are extremely high on my blood work, I just don't understand the need.

[QUOTE="Ubermensch33, post: 117575, member: 18762"] Thanks for all the responses, guys. So my Estradiol (NOT using sensitive method) went from 20.5 to 34.9 [7.6 - 42.6] in the month+ of my TRT regimen. I didn't say anything to the T clinic when they gave me the anastrazole. I'm just not going to take it (also, the clinician wrongly told me the upper range was 35 when he was talking about the jump my estradiol made). I have a consult with Defy on Wednesday. I'm fine with having a need to take an AI. But without symptoms, and without levels that are extremely high on my blood work, I just don't understand the need. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038