johndoesmith
Member
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814970/
"There was no change in the serum concentration of prostate-specific antigen in any group" - https://www.ncbi.nlm.nih.gov/pubmed/8637535
"The prostate saturation model suggests that the androgen receptor (AR) is saturated at serum testosterone levels of 150–200 ng/dl, and that additional serum testosterone above this level has limited, if any, effects within the prostate. Indeed, studies in the modern era of PSA assessments indicate that TST does not affect prostate size, intraprostatic testosterone levels, or prostate-cancer progression, provided the baseline serum testosterone level is greater than this AR saturation point" - http://www.nature.com/nrurol/journal/v11/n9/abs/nrurol.2014.163.html
" In other words, there is a limit to the ability of androgens to stimulate prostate growth, whether benign or malignant. This explains why serum prostate-specific antigen (PSA) does not correlate with serum T concentrations in a normal population, [15] yet PSA declines dramatically with experimental androgen deprivation in healthy volunteers, [16] and why 5 alpha reductase inhibitors that produce castrate-level dihydrotestosterone (DHT) concentrations reduce serum PSA by approximately half. [17] Yet administration of supraphysiological T doses to healthy volunteers for as long as 9 months does not result in increased PSA or prostate volume." - http://www.ajandrology.com/article....ssue=2;spage=206;epage=211;aulast=Morgentaler
"No significant change occurred in the prostate volume or serum PSA levels at any dose of exogenous testosterone." "A total of 31 healthy volunteers 21 to 39 years old were randomized to receive either 100, 250 or 500 mg. testosterone via intramuscular injection once a week for 15 weeks"
- https://www.ncbi.nlm.nih.gov/pubmed/9649259
http://www.jurology.com/article/S0022-5347(11)03846-8/abstract
This study talks mostly about androgen saturation theory. It suggests that men with total testosterone lower than 250ng/dl may experience increased PSA, but those >250ng/dl won't.
"There was no change in the serum concentration of prostate-specific antigen in any group" - https://www.ncbi.nlm.nih.gov/pubmed/8637535
"The prostate saturation model suggests that the androgen receptor (AR) is saturated at serum testosterone levels of 150–200 ng/dl, and that additional serum testosterone above this level has limited, if any, effects within the prostate. Indeed, studies in the modern era of PSA assessments indicate that TST does not affect prostate size, intraprostatic testosterone levels, or prostate-cancer progression, provided the baseline serum testosterone level is greater than this AR saturation point" - http://www.nature.com/nrurol/journal/v11/n9/abs/nrurol.2014.163.html
" In other words, there is a limit to the ability of androgens to stimulate prostate growth, whether benign or malignant. This explains why serum prostate-specific antigen (PSA) does not correlate with serum T concentrations in a normal population, [15] yet PSA declines dramatically with experimental androgen deprivation in healthy volunteers, [16] and why 5 alpha reductase inhibitors that produce castrate-level dihydrotestosterone (DHT) concentrations reduce serum PSA by approximately half. [17] Yet administration of supraphysiological T doses to healthy volunteers for as long as 9 months does not result in increased PSA or prostate volume." - http://www.ajandrology.com/article....ssue=2;spage=206;epage=211;aulast=Morgentaler
"No significant change occurred in the prostate volume or serum PSA levels at any dose of exogenous testosterone." "A total of 31 healthy volunteers 21 to 39 years old were randomized to receive either 100, 250 or 500 mg. testosterone via intramuscular injection once a week for 15 weeks"
- https://www.ncbi.nlm.nih.gov/pubmed/9649259
http://www.jurology.com/article/S0022-5347(11)03846-8/abstract
This study talks mostly about androgen saturation theory. It suggests that men with total testosterone lower than 250ng/dl may experience increased PSA, but those >250ng/dl won't.
