I completely agree with you, the researchers use these poor protocols like 200mg E14D, which is extremely outdated, not to mention cookie cutter, and there's no mention of dialing in E2 amongst other hormones, nor is there any E2 measurements AFAIK.
I'd love to see what that study you're referring to would be like if they used an INDIVIDUALIZED protocol for each, with more modern protocols like 60mg E3.5D or even EOD for low SHBG guys, and dialing in of E2 using LC/MS-MS testing.
What's impressive is even with that poor excuse of a protocol, the men had vast improvements.
Although I imagine the problem is with the variance in individual protocols by definition not being standardized, which is a problem for research.
This study in the OP is a bit more modern, but still only evaluated total testosterone, no mention of E2, and used E84D injections of nebido which according to nebido leaves most men around 450-500ish from week 6-12.
Not exactly what many of us here would be happy with.
