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General Health & Fitness
Nutrition and Supplements
sodium bicarbonate and exercise performance
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<blockquote data-quote="madman" data-source="post: 208396" data-attributes="member: 13851"><p><strong>Fig. 1 <u>Schematic representation of the mechanism of HCO3</u> - <u>absorption in the stomach and the impact of sodium bicarbonate ingestion on muscle metabolism and selected blood parameters</u>. Sodium bicarbonate ingestion increases the concentration of HCO3 - in the stomach lumen, some of which neutralizes HCl to form CO2 and increases luminal pH. The rise in pH stimulates the Cl- /HCO3 - antiporter in the parietal cells, which transports HCO3 - into the extracellular fluid. This transport is coupled with the H-K-ATPase pump that secretes H+ into the stomach lumen to restore the pH. This results in increased pH and HCO3 - concentration, which increases the activity of monocarboxylate transporters (MCT1 and MCT4, represented in light blue), thereby enhancing the transport of H+ out of muscle cells and improving intramuscular acid-base balance. Improved pH control in the muscle cells allows higher glycolytic rates, resulting in higher rates of ATP production and higher muscle and blood lactate concentrations. Solid lines indicate reactions. Dashed lines indicate transport across membranes or movement within the cell compartment. Created using BioRender.com</strong></p><p><strong>[ATTACH=full]16571[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 208396, member: 13851"] [B]Fig. 1 [U]Schematic representation of the mechanism of HCO3[/U] - [U]absorption in the stomach and the impact of sodium bicarbonate ingestion on muscle metabolism and selected blood parameters[/U]. Sodium bicarbonate ingestion increases the concentration of HCO3 - in the stomach lumen, some of which neutralizes HCl to form CO2 and increases luminal pH. The rise in pH stimulates the Cl- /HCO3 - antiporter in the parietal cells, which transports HCO3 - into the extracellular fluid. This transport is coupled with the H-K-ATPase pump that secretes H+ into the stomach lumen to restore the pH. This results in increased pH and HCO3 - concentration, which increases the activity of monocarboxylate transporters (MCT1 and MCT4, represented in light blue), thereby enhancing the transport of H+ out of muscle cells and improving intramuscular acid-base balance. Improved pH control in the muscle cells allows higher glycolytic rates, resulting in higher rates of ATP production and higher muscle and blood lactate concentrations. Solid lines indicate reactions. Dashed lines indicate transport across membranes or movement within the cell compartment. Created using BioRender.com [ATTACH type="full"]16571[/ATTACH][/B] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
sodium bicarbonate and exercise performance
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