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The E2 thing is certainly complicated. After 6 weeks on TRT my E2 went from about 8 to 18. Then after another 10 weeks up to 31. Then about 6 weeks later (two weeks ago) up to about 36 (on the EOD protocol from E3.5 days) So with the same dosage of T it has not stabilized over 6 1/2 to 7 months.