Sleep Duration and Inflammation (CRP) in Adults

Nelson Vergel

Founder, ExcelMale.com
Sleep Duration and C-Reactive Protein in US Adults.
Richardson MR, et al. South Med J. 2017.

South Med J. 2017 Apr;110(4):314-317. doi: 10.14423/SMJ.0000000000000632

Abstract

OBJECTIVE: To use gender-stratified logistic regression analysis to examine the associations between elevated C-reactive protein (CRP; >3-10 mg/L) and sleep duration.

METHODS: The study sample included male (n = 5033) and female (n = 4917) adult (20 years old and older) participants in the 2007-2010 National Health and Nutrition Examination Survey. Sleep duration was categorized as short (≤6 hours/day), adequate (7-8 hours/day), or long (≥9 hours/day). Logistic regression models were adjusted for age, race, smoking status, physical activity, and waist circumference.

RESULTS: Analysis revealed significantly (P = 0.0151) higher odds of elevated CRP in men reporting ≤6 hours/day of sleep (odds ratio 1.26, 95% confidence interval 1.05-1.52) when compared with a referent group of men reporting 7 to 8 hours/day of sleep. Similar associations were not revealed in women.

CONCLUSIONS: Short sleep duration was significantly associated with elevated serum CRP concentration independent of waist circumference and moderate physical activity in men but not in women.

CRP.webp
 
The Daily Telegraph reports:
"The most at-risk group was adults under 60 years of age who slept five hours or fewer a night. They increased their risk of developing cardiovascular disease more than threefold ... Women who skimped on sleep ... were more than two-and-a-half times as likely to develop cardiovascular disease."
 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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