ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
skin permeation assays for drugs presenting biopharmaceutical limitations- TST
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 206672" data-attributes="member: 13851"><p><em><strong>*Androgen receptors are expressed in sebocytes, hair follicles, dermal papilla, and keratinocytes.<u> Hence, TST plays an important role in sebum production, control hair growth as well as hair loss, epidermal growth, and differentiation</u> (Choudhry et al., 1992).</strong> <strong><u>The mechanism of action of TST occurs by its local conversion to dihydrotestosterone (DHT) by 5α-reductase (type 1)</u>.<u> DHT then binds to the androgen receptor</u>. This means that the increase of TST leads to an increase in DHT concentrations, which is associated with hair loss (alopecia) (Riggs et al., 2002; Shapiro and Price, 1998). The action of this hormone is regulated by cell-type-specific activation or deactivation in human skin. <u>In physiological conditions, fibroblasts present in the dermis activate mainly TST to DHT</u>. In contrast, keratinocytes present in the epidermis deactivate TST, forming androstenedione (Münster et al., 2003).</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The higher concentration of TST in men is associated with a thicker epidermis, and a greater amount of collagen and moisture compared to women skin (Markova et al., 2004). <u>On the other hand, the higher levels of TST in males stimulate a large production of sebum, leading to a fatty glow and coarser pores of the skin </u>(Baumann, 2002). TST can also perturb the epidermal barrier homeostasis considering that studies showed a retard in barrier development of skin fetus and slowed barrier recovery in adult skin (Kao et al., 2001). Other negative effects include the inhibition of skin wound healing in males and the TST association with an enhanced inflammatory response (Ashcroft and Mills, 2002). In contrast, a reduction in physiological levels of the hormone has also a negative impact on epidermal skin moisture, elasticity, and thickness (Bernard et al., 2012). In these cases, the local hormone replacement with TST can be advantageous to improve the aspect of skin aging in men.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 206672, member: 13851"] [I][B]*Androgen receptors are expressed in sebocytes, hair follicles, dermal papilla, and keratinocytes.[U] Hence, TST plays an important role in sebum production, control hair growth as well as hair loss, epidermal growth, and differentiation[/U] (Choudhry et al., 1992).[/B] [B][U]The mechanism of action of TST occurs by its local conversion to dihydrotestosterone (DHT) by 5α-reductase (type 1)[/U].[U] DHT then binds to the androgen receptor[/U]. This means that the increase of TST leads to an increase in DHT concentrations, which is associated with hair loss (alopecia) (Riggs et al., 2002; Shapiro and Price, 1998). The action of this hormone is regulated by cell-type-specific activation or deactivation in human skin. [U]In physiological conditions, fibroblasts present in the dermis activate mainly TST to DHT[/U]. In contrast, keratinocytes present in the epidermis deactivate TST, forming androstenedione (Münster et al., 2003). *The higher concentration of TST in men is associated with a thicker epidermis, and a greater amount of collagen and moisture compared to women skin (Markova et al., 2004). [U]On the other hand, the higher levels of TST in males stimulate a large production of sebum, leading to a fatty glow and coarser pores of the skin [/U](Baumann, 2002). TST can also perturb the epidermal barrier homeostasis considering that studies showed a retard in barrier development of skin fetus and slowed barrier recovery in adult skin (Kao et al., 2001). Other negative effects include the inhibition of skin wound healing in males and the TST association with an enhanced inflammatory response (Ashcroft and Mills, 2002). In contrast, a reduction in physiological levels of the hormone has also a negative impact on epidermal skin moisture, elasticity, and thickness (Bernard et al., 2012). In these cases, the local hormone replacement with TST can be advantageous to improve the aspect of skin aging in men.[/B][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
skin permeation assays for drugs presenting biopharmaceutical limitations- TST
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top