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<blockquote data-quote="Cataceous" data-source="post: 195617" data-attributes="member: 38109"><p>Here's another possible factor in skin aging: falling levels of oxytocin.[<a href="https://jddonline.com/articles/dermatology/S1545961620P1146X" target="_blank">R</a>]</p><p></p><p style="margin-left: 20px"><em>ABSTRACT</em></p> <p style="margin-left: 20px"><em>Background: Studies have shown oxytocin (OT) and its carrier protein neurophysin 1 are found in the epidermis. The oxytocin receptor, which is found on human fibroblasts has been shown, when activated by oxytocin, to inhibit senescence-associated secretory phenotype (SASP). SASP activation induces the release of proinflammatory cytokines which contribute to skin aging. Therefore, its inhibition by oxytocin would constitute a protective mechanism. This pilot study was designed to explore clinical evidence of oxytocin levels correlating to the skin’s appearance in subjects. </em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Methods: Oxytocin levels, facial photographs, and lifetime sun exposure questionnaires from six female subjects aged 48–61 years old were analyzed. A skin age score (SAS) was determined for each subject and was compared to the expected average SAS for each subject based on their age to determine a percentage in change, if any. A reduction in SAS would indicate more youthful appearing skin than the average person of that age. </em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Results: All subjects had at least some reduction in SAS score as compared to their expected score. <strong>An almost linear relationship of SAS reduction as related to OT levels was found, showing a correlation of more youthful appearing skin with higher OT levels.</strong></em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Conclusions: This study links previously published evidence of oxytocin’s protective role against inflammatory cytokine release in the skin with clinical evidence of OT levels correlating with SAS scores. Furthermore, it shows <strong>OT is likely inducing a protective function in the epidermis in the case of sun exposure and possibly with intrinsic aging</strong>.</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 195617, member: 38109"] Here's another possible factor in skin aging: falling levels of oxytocin.[[URL='https://jddonline.com/articles/dermatology/S1545961620P1146X']R[/URL]] [INDENT][I]ABSTRACT[/I][/INDENT] [INDENT][I]Background: Studies have shown oxytocin (OT) and its carrier protein neurophysin 1 are found in the epidermis. The oxytocin receptor, which is found on human fibroblasts has been shown, when activated by oxytocin, to inhibit senescence-associated secretory phenotype (SASP). SASP activation induces the release of proinflammatory cytokines which contribute to skin aging. Therefore, its inhibition by oxytocin would constitute a protective mechanism. This pilot study was designed to explore clinical evidence of oxytocin levels correlating to the skin’s appearance in subjects. [/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Methods: Oxytocin levels, facial photographs, and lifetime sun exposure questionnaires from six female subjects aged 48–61 years old were analyzed. A skin age score (SAS) was determined for each subject and was compared to the expected average SAS for each subject based on their age to determine a percentage in change, if any. A reduction in SAS would indicate more youthful appearing skin than the average person of that age. [/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Results: All subjects had at least some reduction in SAS score as compared to their expected score. [B]An almost linear relationship of SAS reduction as related to OT levels was found, showing a correlation of more youthful appearing skin with higher OT levels.[/B][/I][/INDENT] [INDENT][I] [/I][/INDENT] [INDENT][I]Conclusions: This study links previously published evidence of oxytocin’s protective role against inflammatory cytokine release in the skin with clinical evidence of OT levels correlating with SAS scores. Furthermore, it shows [B]OT is likely inducing a protective function in the epidermis in the case of sun exposure and possibly with intrinsic aging[/B].[/I][/INDENT] [/QUOTE]
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