ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Sildenafil Slow Release (SR) Empower?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Jasen Bruce" data-source="post: 80748" data-attributes="member: 14"><p>Sustained release PDE-5 capsules are still commonly prescribed to be taken 60 min prior to sex. </p><p></p><p>The reason that compounding pharmacies compound PDE-5 inhibitor capsules as a sustained release is because they cannot make a tablet or capsule that is too close to the commercial equivalent. In order to justify compounding a generic, there must be at least one change from commercial product, usually the change is in dosage form, strength, and/or ingredient combination. By adding a sustained release to sildenafil capsules they are essentially creating a new product that is not available commercially.</p><p></p><p>Methylcellulose is added to to the sildenafil capsule to provide the "sustained release". It does this by binding the powder together which slows the ingredient break down, dispersion, and absorption in the gut immediately after ingestion. Although there are no studies on the pharmacokinetics of SR sildenafil capsules vs immediate release tablets, most patients respond to the higher dosage of sildenafil SR capsules within one hour of taking it (100mg+). The SR does not prevent the ingredients from being absorbed immediately, instead it just slows down the overall metabolism of the drug with the intention of extending its duration. There is no way of knowing how individuals respond since even dissolution tests do not represent the individual person's metabolism. Vinegar is not a valid test itself since you do not know how the active/inactive ingredients react with vinegar (independent of body fluids) which can alter the results. </p><p></p><p>Since you are on a lower dose (36mg) than commonly prescribed, this might be the reason for your response. </p><p></p><p>If you are looking for a compounded PDE-5 that is not sustained release, have your doctor prescribe a sublingual troche or oral dissolvable tablet (ODT). Both contain just sildenafil with no methycellulose. Both the troche and ODT can also be taken orally and they should metabolize the same as a tablet, possibly faster since the body does not have to break down the hard tablet. </p><p></p><p>I work with urologists who prescribe thousands of compounded PDE-5 inhibitors through Empower and all have their patients take 60 min prior to sex with positive outcomes, less the statistically consistent few that do not respond to PDE5 in general.</p></blockquote><p></p>
[QUOTE="Jasen Bruce, post: 80748, member: 14"] Sustained release PDE-5 capsules are still commonly prescribed to be taken 60 min prior to sex. The reason that compounding pharmacies compound PDE-5 inhibitor capsules as a sustained release is because they cannot make a tablet or capsule that is too close to the commercial equivalent. In order to justify compounding a generic, there must be at least one change from commercial product, usually the change is in dosage form, strength, and/or ingredient combination. By adding a sustained release to sildenafil capsules they are essentially creating a new product that is not available commercially. Methylcellulose is added to to the sildenafil capsule to provide the "sustained release". It does this by binding the powder together which slows the ingredient break down, dispersion, and absorption in the gut immediately after ingestion. Although there are no studies on the pharmacokinetics of SR sildenafil capsules vs immediate release tablets, most patients respond to the higher dosage of sildenafil SR capsules within one hour of taking it (100mg+). The SR does not prevent the ingredients from being absorbed immediately, instead it just slows down the overall metabolism of the drug with the intention of extending its duration. There is no way of knowing how individuals respond since even dissolution tests do not represent the individual person's metabolism. Vinegar is not a valid test itself since you do not know how the active/inactive ingredients react with vinegar (independent of body fluids) which can alter the results. Since you are on a lower dose (36mg) than commonly prescribed, this might be the reason for your response. If you are looking for a compounded PDE-5 that is not sustained release, have your doctor prescribe a sublingual troche or oral dissolvable tablet (ODT). Both contain just sildenafil with no methycellulose. Both the troche and ODT can also be taken orally and they should metabolize the same as a tablet, possibly faster since the body does not have to break down the hard tablet. I work with urologists who prescribe thousands of compounded PDE-5 inhibitors through Empower and all have their patients take 60 min prior to sex with positive outcomes, less the statistically consistent few that do not respond to PDE5 in general. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Sildenafil Slow Release (SR) Empower?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top