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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Should You Apply Testosterone Gel or Cream on Your Testicles for Best Absorption?
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<blockquote data-quote="Nelson Vergel" data-source="post: 4114" data-attributes="member: 3"><p>All commercially available testosterone gels approved in the United States by the Food and Drug Administration are recommended for application on different skin areas, but none are recommended for use on testicular skin due to their alcohol content and the fact that dehydrotestosterone (DHT) conversion is higher on that application site. DHT is a metabolite of testosterone metabolism responsible for sexual drive and erectile function, but high levels can worsen hair loss on scalp and possibly increase prostate volume. In the past, there was a testosterone patch approved for scrotal application but it quickly became unpopular due to its inconvenience. </p><p></p><p>Some compounding pharmacies make liposomal creams that are not irritant to scrotal skin. Some men who have used <a href="https://www.excelmale.com/forum/threads/434-WARNING-Propecia-%28finasteride%29-or-Proscar-can-deplete-your-testosterone-and-cause-ED" target="_blank">Propecia or Proscar (finasteride)</a> in the past to prevent hair loss or prostate inflammation were later found to have irreversible issues with low DHT and decreased sex drive and/or erectile function. These scrotal creams can help those men increase their DHT to levels that can improve sexual function.</p><p></p><p></p><p>Here is a study done in the late 80's that showed the increase propensity for scrotal skin to cause more DHT conversion.</p><p></p><p><strong>Androgen therapy of hypogonadal men with transscrotal testosterone systems</strong></p><p></p><p>The American Journal of Medicine</p><p>Volume 83, Issue 3 , Pages 471-478, September 1987</p><p></p><p><strong>Abstract</strong></p><p></p><p>The need for improved controlled delivery of testosterone to hypogonadal men stimulated the development of a self-adherent transscrotal testosterone system to provide programmed testosterone delivery through the uniquely permeable scrotal skin. In this short- and long-term efficacy trial, the responses of testosterone and its metabolites to the application of transscrotal testosterone systems of varying testosterone content were compared with the response to 200 mg of testosterone enanthate. Daily transscrotal testosterone system administration resulted in a rapid increase of testosterone and bioavailable, nonsex hormone binding globulin-bound testosterone levels to normal, peaking at two hours, followed by a slow decline over 23 hours, resembling the diurnal variation of endogenous testosterone. One year of daily transscrotal testosterone system therapy demonstrated continued reliable absorption of testosterone and suppression to normal of the luteinizing hormone in two of three patients. <strong>There was a greatly disproportionate increase of serum dihydrotestosterone (DHT) over testosterone, suggesting 5-alpha reduction at the scrotal site. </strong>The subjects reported marked subjective improvement. Thus, the transscrotal testosterone system is a novel, effective, and well-tolerated method of delivering testosterone to hypogonadal patients.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 4114, member: 3"] All commercially available testosterone gels approved in the United States by the Food and Drug Administration are recommended for application on different skin areas, but none are recommended for use on testicular skin due to their alcohol content and the fact that dehydrotestosterone (DHT) conversion is higher on that application site. DHT is a metabolite of testosterone metabolism responsible for sexual drive and erectile function, but high levels can worsen hair loss on scalp and possibly increase prostate volume. In the past, there was a testosterone patch approved for scrotal application but it quickly became unpopular due to its inconvenience. Some compounding pharmacies make liposomal creams that are not irritant to scrotal skin. Some men who have used [URL="https://www.excelmale.com/forum/threads/434-WARNING-Propecia-%28finasteride%29-or-Proscar-can-deplete-your-testosterone-and-cause-ED"]Propecia or Proscar (finasteride)[/URL] in the past to prevent hair loss or prostate inflammation were later found to have irreversible issues with low DHT and decreased sex drive and/or erectile function. These scrotal creams can help those men increase their DHT to levels that can improve sexual function. Here is a study done in the late 80's that showed the increase propensity for scrotal skin to cause more DHT conversion. [B]Androgen therapy of hypogonadal men with transscrotal testosterone systems[/B] The American Journal of Medicine Volume 83, Issue 3 , Pages 471-478, September 1987 [B]Abstract[/B] The need for improved controlled delivery of testosterone to hypogonadal men stimulated the development of a self-adherent transscrotal testosterone system to provide programmed testosterone delivery through the uniquely permeable scrotal skin. In this short- and long-term efficacy trial, the responses of testosterone and its metabolites to the application of transscrotal testosterone systems of varying testosterone content were compared with the response to 200 mg of testosterone enanthate. Daily transscrotal testosterone system administration resulted in a rapid increase of testosterone and bioavailable, nonsex hormone binding globulin-bound testosterone levels to normal, peaking at two hours, followed by a slow decline over 23 hours, resembling the diurnal variation of endogenous testosterone. One year of daily transscrotal testosterone system therapy demonstrated continued reliable absorption of testosterone and suppression to normal of the luteinizing hormone in two of three patients. [B]There was a greatly disproportionate increase of serum dihydrotestosterone (DHT) over testosterone, suggesting 5-alpha reduction at the scrotal site. [/B]The subjects reported marked subjective improvement. Thus, the transscrotal testosterone system is a novel, effective, and well-tolerated method of delivering testosterone to hypogonadal patients. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Should You Apply Testosterone Gel or Cream on Your Testicles for Best Absorption?
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