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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Should We Be Managing Estradiol and Hematocrit in Men on Testosterone Replacement?
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<blockquote data-quote="Nelson Vergel" data-source="post: 71190" data-attributes="member: 3"><p>If I had a medical license, I would definitely do something about a hematocrit of 60 with the non-TRT CDV data we have.</p><p></p><p>We have all watched Morgentaler's lecture and he never says to let go of hematocrit monitoring. In fact, four medical guidelines include hematocrit as part of their recommended monitoring recommendations. Enough data for attorneys hungry for medical malpractice lawsuits?</p><p></p><p><strong><a href="https://www.excelmale.com/content.php?209-Dr-Morgentaler-Facts-aboutf-Testosterone-and-Heart-Disease-Risk" target="_blank">Dr Morgentaler Clarifies Misperceptions of Testosterone and Heart Disease Risk</a></strong></p><p></p><p>Most men using doses under 150 mg per week of testosterone may not have significant hematocrit increases that persist over 1 year. However, there are a few (no data on the prevalence) whose hematocrit increase does not stabilize under 54. You are right when you say we have no data from a TRT study that plots hematocrit with cardiovascular disease incidence. We will probably never have one of those since most of the studies presented in the past few years do not seem to report hematocrit and do not include phlebotomies. Most studies show average total T of under 600 ng/dL anyway. Many men on ExcelMale have TT over 600 ng/dL.</p><p></p><p>I have only had one phlebotomy in 27 years. But some are not as lucky. I have seen guys with increased blood pressure and fatigue walking around with hematocrit of over 60 unmanaged by their doctors. Should we not address this issue?</p><p></p><p>[ATTACH]3627[/ATTACH]</p><p></p><p>Let's assume that no heart attacks or stroke occur with higher hematocrit in men on testosterone. There are other issues like blood pressure that come into play.</p><p></p><p>"<span style="color: #3E3E3E"><span style="font-family: 'Arial'">It has been hypothesized that an increased hemoglobin level elevates blood pressure. The present study investigated the association between hemoglobin level and systolic blood pressure and diastolic blood pressure in healthy persons. The study population was composed of 101 377 whole blood and plasma donors, who made 691 107 visits to the blood bank. At each visit, hemoglobin level and blood pressure were measured as part of the standard procedure before a blood donation. We used repeated measurement analysis to analyze the data. We used generalized estimating equation models to assess the between-person effect and linear mixed models to assess the within-person effect. All of the analyses were done separately for men and women. In the study population, 50% were men. The mean age in men was 49.3 years (±12.5 years), and in women it was 42.4 years (±13.7 years). <strong>Hemoglobin level was positively associated with both systolic and diastolic blood pressures. </strong>With respect to the between-person effect, regression coefficients for systolic blood pressure were 1.3 mm Hg per millimole per liter increase in hemoglobin level for men and 1.8 mm Hg per millimole per liter increase in hemoglobin level for women. With respect to the within-person effect, regression coefficients for systolic blood pressure were 0.7 mm Hg and 0.9 mm Hg per millimole per liter increase in hemoglobin level, for men and women, respectively. For diastolic blood pressure, results were comparable. The results show that hemoglobin level is positively associated with both systolic and diastolic blood pressures in healthy individuals. We observed consistent effects between persons but also within persons."</span></span><strong><a href="http://hyper.ahajournals.org/content/60/4/936" target="_blank">http://hyper.ahajournals.org/content/60/4/936</a></strong></p><p><strong></strong></p><p><strong></strong>I am looking forward to the evidence you mentioned that you will get in the next few weeks. I am eager to learn new things that may change my opinion!</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 71190, member: 3"] If I had a medical license, I would definitely do something about a hematocrit of 60 with the non-TRT CDV data we have. We have all watched Morgentaler's lecture and he never says to let go of hematocrit monitoring. In fact, four medical guidelines include hematocrit as part of their recommended monitoring recommendations. Enough data for attorneys hungry for medical malpractice lawsuits? [B][URL="https://www.excelmale.com/content.php?209-Dr-Morgentaler-Facts-aboutf-Testosterone-and-Heart-Disease-Risk"]Dr Morgentaler Clarifies Misperceptions of Testosterone and Heart Disease Risk[/URL][/B] Most men using doses under 150 mg per week of testosterone may not have significant hematocrit increases that persist over 1 year. However, there are a few (no data on the prevalence) whose hematocrit increase does not stabilize under 54. You are right when you say we have no data from a TRT study that plots hematocrit with cardiovascular disease incidence. We will probably never have one of those since most of the studies presented in the past few years do not seem to report hematocrit and do not include phlebotomies. Most studies show average total T of under 600 ng/dL anyway. Many men on ExcelMale have TT over 600 ng/dL. I have only had one phlebotomy in 27 years. But some are not as lucky. I have seen guys with increased blood pressure and fatigue walking around with hematocrit of over 60 unmanaged by their doctors. Should we not address this issue? [ATTACH=CONFIG]3627[/ATTACH] Let's assume that no heart attacks or stroke occur with higher hematocrit in men on testosterone. There are other issues like blood pressure that come into play. "[COLOR=#3E3E3E][FONT=HelveticaNeueExtended][FONT=arial]It has been hypothesized that an increased hemoglobin level elevates blood pressure. The present study investigated the association between hemoglobin level and systolic blood pressure and diastolic blood pressure in healthy persons. The study population was composed of 101 377 whole blood and plasma donors, who made 691 107 visits to the blood bank. At each visit, hemoglobin level and blood pressure were measured as part of the standard procedure before a blood donation. We used repeated measurement analysis to analyze the data. We used generalized estimating equation models to assess the between-person effect and linear mixed models to assess the within-person effect. All of the analyses were done separately for men and women. In the study population, 50% were men. The mean age in men was 49.3 years (±12.5 years), and in women it was 42.4 years (±13.7 years). [B]Hemoglobin level was positively associated with both systolic and diastolic blood pressures. [/B]With respect to the between-person effect, regression coefficients for systolic blood pressure were 1.3 mm Hg per millimole per liter increase in hemoglobin level for men and 1.8 mm Hg per millimole per liter increase in hemoglobin level for women. With respect to the within-person effect, regression coefficients for systolic blood pressure were 0.7 mm Hg and 0.9 mm Hg per millimole per liter increase in hemoglobin level, for men and women, respectively. For diastolic blood pressure, results were comparable. The results show that hemoglobin level is positively associated with both systolic and diastolic blood pressures in healthy individuals. We observed consistent effects between persons but also within persons."[/FONT][/FONT][/COLOR][B][URL]http://hyper.ahajournals.org/content/60/4/936[/URL] [/B]I am looking forward to the evidence you mentioned that you will get in the next few weeks. I am eager to learn new things that may change my opinion! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Should We Be Managing Estradiol and Hematocrit in Men on Testosterone Replacement?
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