ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Should We Be Managing Estradiol and Hematocrit in Men on Testosterone Replacement?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="J. Keith Nichols MD" data-source="post: 71174" data-attributes="member: 15691"><p>The mechanism of increase in H/H is the same. You are presenting baseline values and prospective studies. To know if a increase in heart attacks, strokes, or DVTs occurs with the increase in H/H seen with TRT, then one must perform a interventional study and see what happens when you actually give testosterone and increase H/H. Baseline observations don't mean causation. How do we discount over 50 years of interventional studies without a increase in cardiac events or DVTs wirh T administration. These are associations which do not prove causation. No different than the studies where men with high estrogen levels died of heart attacks and strokes. Makes perfect sense. These men were obese with high visceral body fat and therefore high E2. The E2 didn't cause their heart attacks it was all the increased risk factors for MIs that goes along with being obese. The E2 was just a passive bystander. As I have described, give a man E2 that Is undergoing ADT and you protect them. So the studies you have provided say nothing about what happens when a man is actually given testosterone and his H/H increases. 50 years of TRT research prove otherwise. </p><p>You are extrapolating the effects seen with people with high Hct of unknown origin to that of patients increasing Hct on TRT which has not been shown. Don't extrapolate. </p><p>Morgentaler et al. "Testosterone therapy and cardiovascular risk: advances and controversies" Mayo cling proceedings 2015</p></blockquote><p></p>
[QUOTE="J. Keith Nichols MD, post: 71174, member: 15691"] The mechanism of increase in H/H is the same. You are presenting baseline values and prospective studies. To know if a increase in heart attacks, strokes, or DVTs occurs with the increase in H/H seen with TRT, then one must perform a interventional study and see what happens when you actually give testosterone and increase H/H. Baseline observations don't mean causation. How do we discount over 50 years of interventional studies without a increase in cardiac events or DVTs wirh T administration. These are associations which do not prove causation. No different than the studies where men with high estrogen levels died of heart attacks and strokes. Makes perfect sense. These men were obese with high visceral body fat and therefore high E2. The E2 didn't cause their heart attacks it was all the increased risk factors for MIs that goes along with being obese. The E2 was just a passive bystander. As I have described, give a man E2 that Is undergoing ADT and you protect them. So the studies you have provided say nothing about what happens when a man is actually given testosterone and his H/H increases. 50 years of TRT research prove otherwise. You are extrapolating the effects seen with people with high Hct of unknown origin to that of patients increasing Hct on TRT which has not been shown. Don't extrapolate. Morgentaler et al. "Testosterone therapy and cardiovascular risk: advances and controversies" Mayo cling proceedings 2015 [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Should We Be Managing Estradiol and Hematocrit in Men on Testosterone Replacement?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top