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I use to struggle with my estrogen, as well as had chest issues such as itchiness on my chest/ armpit areas. Gyno once too. 2 years later, I think some of it was in my head. When my estrogen was a 20 or so I'd be happy yet still had sides as mentioned above. But I was irritable and weak. Fast forward 2 years, I couldn't imagine letting it get thst low. Last test on the sensitive showed me at 44. I no longer use arimidex like I used too. I feel stronger too. Now, I only take a sliver I cut off of a 1mg tab every so often. Sometimes weeks.