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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Should I be concerned?
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<blockquote data-quote="madman" data-source="post: 205834" data-attributes="member: 13851"><p>The only way T would have crystallized is if it was stored at low temperatures.</p><p></p><p>Although far from common it can happen with big pharma let alone compounded T.</p><p></p><p>It will almost look like tiny pieces of fiberglass throughout the oily solution.</p><p></p><p>As others have stated warming the vial would redissolve any crystals that have formed</p><p></p><p>It can still be used.</p><p></p><p></p><p></p><p></p><p><strong>post#15</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/how-long-after-the-best-use-date-bud-does-t-cyp-prop-retain-its-full-efficacy.20804/#post-175806[/URL]</p><p></p><p><strong>Depo®-Testosterone (testosterone cypionate injection, USP) CIII</strong></p><p></p><p>Pfizer Kalamazoo site has investigated the product complaints on Depo®- Testosterone regarding crystallization of contents in 100 and 200 mg/mL vials. <strong><em>The investigation has found that although crystals have been observed, the <u>formulation of crystals does not impact patient safety, efficacy, or product quality when the US Product Insert (USPI) instructions are followed prior to administration</u>.</em></strong></p><p><strong><em></em></strong></p><p><strong><em>Depo-Testosterone 100 mg/mL is <u>very highly concentrated</u> and 200 mg/mL is a <u>supersaturated</u> sterile solution for injection,</em></strong> comprised of cottonseed oil, testosterone cypionate, and benzyl alcohol. <strong><em><u>The HIGH CONCENTRATIONS of active ingredients make the product very susceptible to CRYSTALLIZATION when EXPOSED TO TEMPERATURES LOWER THAN THE RANGES RECOMMENDED ON THE LABEL</u> [20°C to 25°C (68°F to 77°F)].</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>The USPI states:</strong></p><p><strong></strong></p><p><strong><em>“Parenteral drug products should be inspected <u>visually for particulate matter and discoloration prior to administration</u>, whenever solution and container permit. <u>Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 205834, member: 13851"] The only way T would have crystallized is if it was stored at low temperatures. Although far from common it can happen with big pharma let alone compounded T. It will almost look like tiny pieces of fiberglass throughout the oily solution. As others have stated warming the vial would redissolve any crystals that have formed It can still be used. [B]post#15[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/how-long-after-the-best-use-date-bud-does-t-cyp-prop-retain-its-full-efficacy.20804/#post-175806[/URL] [B]Depo®-Testosterone (testosterone cypionate injection, USP) CIII[/B] Pfizer Kalamazoo site has investigated the product complaints on Depo®- Testosterone regarding crystallization of contents in 100 and 200 mg/mL vials. [B][I]The investigation has found that although crystals have been observed, the [U]formulation of crystals does not impact patient safety, efficacy, or product quality when the US Product Insert (USPI) instructions are followed prior to administration[/U]. Depo-Testosterone 100 mg/mL is [U]very highly concentrated[/U] and 200 mg/mL is a [U]supersaturated[/U] sterile solution for injection,[/I][/B] comprised of cottonseed oil, testosterone cypionate, and benzyl alcohol. [B][I][U]The HIGH CONCENTRATIONS of active ingredients make the product very susceptible to CRYSTALLIZATION when EXPOSED TO TEMPERATURES LOWER THAN THE RANGES RECOMMENDED ON THE LABEL[/U] [20°C to 25°C (68°F to 77°F)].[/I] The USPI states: [I]“Parenteral drug products should be inspected [U]visually for particulate matter and discoloration prior to administration[/U], whenever solution and container permit. [U]Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Should I be concerned?
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