Shorter men may have a protective FOX03 gene:

Vince · 2025-07-02T07:46:50-0500

For longevity, men who are shorter tend to live longer than taller men. Studies suggest that men under 5'4" or even 5'2" may have a protective advantage, potentially due to factors like the FOX03 gene and lower fasting insulin levels, according to Healthline.

The FOXO3 gene plays a significant role in various cellular processes, including stress resistance, autophagy, and DNA repair, and is strongly associated with longevity. It acts as a transcription factor, meaning it regulates gene expression, and is involved in pathways related to aging and cellular health.

In summary, FOXO3 is a vital protein with a wide range of functions related to cellular health, stress response, and longevity. Its involvement in various biological processes makes it a promising target for interventions aimed at promoting healthy aging and potentially treating age-related diseases, according to research from NCBI.

Vince · 2025-07-02T07:48:10-0500

Thread 'Shorter men live longer: Honolulu-based study'

May 15, 2014

Finally, something we shorties can be happy about!

Short height and long life have a direct connection in Japanese men, according to new research based on the Kuakini Honolulu Heart Program (HHP) and the Kuakini Honolulu-Asia Aging Study (HAAS).
"We split people into two groups - those that were 5-foot-2 and shorter, and 5-4 and taller," said Dr. Bradley Willcox, one of the investigators for the study and a Professor in the University of Hawai`i (UH) John A. Burns School of Medicine's Department of Geriatric Medicine. "The folks that were 5-2 and shorter lived the longest. The range was...