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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Short-acting T therapy to maintain homeostasis that more closely reflects normal physiology
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<blockquote data-quote="madman" data-source="post: 189846" data-attributes="member: 13851"><p><strong>Short-Acting Testosterone: Physiologic?</strong></p><p><span style="color: rgb(44, 130, 201)">Gerwin Westfield, Ursula B Kaiser, Dolores J Lamb, Ranjith Ramasamy </span></p><p></p><p></p><p></p><p></p><p><strong>INTRODUCTION </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><em><strong>Pulsatile secretion of a hormone refers to the intermittent secretion of the hormone in a burst like or episodic manner rather than constantly, with the frequency varying from minutes to hours, determined in part by the half-life of the hormone</strong></em><strong><em>.</em></strong></span><em> In men, communication between the hypothalamus, anterior pituitary, and testes via the hypothalamic-pituitary-gonadal (HPG) axis regulates testosterone (T) secretion, with a negative feedback mechanism controlling circulating levels of T (1). Pulsatile release of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons signals the pulsatile secretion of luteinizing hormone (LH) from the pituitary. Circulating LH, in turn, signals the testes to produce T. Once the appropriate threshold of circulating T levels is achieved, T acts as a negative feedback molecule, signaling to the hypothalamus and pituitary to inhibit secretion of GnRH and LH, respectively (2). <span style="color: rgb(184, 49, 47)"><strong>T levels in a healthy male follow a diurnal variation and circadian rhythm, with levels highest early in the morning and subsequently declining as the day progresses, as a direct result of pulsatile LH secretion (3).</strong></span><span style="color: rgb(0, 0, 0)"> <em>T deficiency (TD) is a condition in which insufficient T levels are attained with one or more symptoms such as fatigue or low energy, depression, low libido, erectile dysfunction, and/or poor concentration (4). The Endocrine Society recently published treatment guidelines for men with symptomatic TD, which recommend a treatment goal of achieving steady-state serum total T concentrations in the mid-normal range (5).</em></span><span style="color: rgb(184, 49, 47)"><em> <strong>A sustained steady-state level of T, however, differs from the normal circadian physiology of a healthy individual. </strong></em></span>The most common hormone treatment for male hypogonadism is an intramuscular (IM) injectable generic testosterone cypionate/enanthate (72.8%), with other therapies including topical gel (25%), transdermal patch (1.2%), long-acting IM injections of testosterone undecanoate (0.18%), and nasal testosterone (0.13%) (6).</em></p><p><em></em></p><p><em></em></p><p></p><p></p><p><strong>TESTOSTERONE PHARMACOKINETICS </strong></p><p></p><p><em><span style="color: rgb(0, 0, 0)">The various testosterone formulations have a wide range of dosing intervals including long-acting preparations: subcutaneous pellets (3 to 6 months), injectable IM testosterone undecanoate (10 weeks); intermediate-acting preparations: IM testosterone cypionate/enanthate (1 to 3 weeks); daily preparations: topical/transdermal formulations; </span></em><span style="color: rgb(0, 0, 0)"><em>and short-acting preparations: oral testosterone undecanoate (twice daily) and nasal testosterone (two to three times daily).</em></span> <span style="color: rgb(184, 49, 47)"><em><strong>All formulations, with the exception of the short-acting ones, have a </strong><u><strong>target of long-term maintenance of sustained steady-state testosterone levels in the mid-normal range</strong></u><strong>, which leads to suppression of the endogenous activity of the HPG axis.</strong></em></span></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)"><em>*</em></span><span style="color: rgb(0, 0, 0)"><em>As previously noted, testosterone levels in young healthy males follow a circadian rhythm. T levels are highest in the morning and lower in the evening hours. </em></span><span style="color: rgb(184, 49, 47)"><em><u>There is significant change within a 24-h period</u>.</em></span><span style="color: rgb(0, 0, 0)"><em> Testosterone itself acts as a negative feedback molecule to the hypothalamus and anterior pituitary. </em></span></strong><span style="color: rgb(184, 49, 47)"><em><u><strong>When T levels are high enough, they signal to reduce GnRH, LH, and FSH secretion, thereby also reducing endogenous testosterone production. This occurs regardless of whether the circulating testosterone is endogenous or exogenous</strong></u><strong>.</strong></em></span><strong><span style="color: rgb(0, 0, 0)"><em> If high levels of testosterone are given exogenously for extended periods of time, this can result in negative feedback to the hypothalamus and anterior pituitary, disrupting normal HPG regulation. </em></span></strong></p><p></p><p></p><p></p><p></p><p><em>Topical gel formulations achieve a sustained mid-normal T level with a once-daily application (8). While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, the sustained T levels result in inhibition of HPG axis activity (9). The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9). <span style="color: rgb(184, 49, 47)"><em><strong>Nasal administration of T (4.5% testosterone nasal gel, Natesto) allows for rapid absorption through the nasal mucosa such that serum T levels reach a peak concentration in ∼40 min. Once in the circulation, the T is quickly metabolized, with a return to near baseline T levels in 3–6 h</strong> (11). Therefore, multiple administrations of nasal T throughout the day (three times daily) maintain normal mean serum T levels over 24 h. The fluctuations in T levels potentially minimize the duration of exposure to exogenous T that is suppressive to the HPG axis, compared to other available T therapies. </em></span></em></p><p></p><p></p><p></p><p></p><p><strong>FINAL THOUGHTS </strong></p><p></p><p><span style="color: rgb(184, 49, 47)"><strong><em>Endocrine systems are regulated dynamically in response to positive or negative stimuli within a homeostatic environment. Modalities of T therapy evolved to extend the dosing interval and maintain sustained “steady-state” T levels. Long-acting TTh can inhibit the HPG axis, which in turn suppresses pituitary LH and FSH secretion, reducing circulating levels of LH and FSH and endogenous T production (Figure 1). </em></strong></span><em><span style="color: rgb(44, 130, 201)"><strong><u>These endocrine changes result in suppression of spermatogenesis and infertility, as well as having other side effects</u>.</strong></span> The detrimental impact on sperm production from these long-acting testosterone therapies led to the use of many off-label products. The use of clomiphene citrate to stimulate gonadotropin production and subsequently increase testosterone levels is used to treat hypogonadism, while also trying to preserve fertility.</em></p><p></p><p><strong><span style="color: rgb(184, 49, 47)"><u><em>Short-acting T therapy, consisting of several doses of T with a shorter half-life throughout the day, minimizes inhibition of the HPG axis and reduces the impairment of spermatogenesis</em></u><em>. </em></span><em><span style="color: rgb(44, 130, 201)">Utilizing FDA approved, shorter-acting forms of T therapy to maintain homeostasis that more closely reflects normal physiology offers great promise for the treatment of men with hypogonadism—an advantage over long-acting formulations. </span></em></strong><em>This therapy would allow the use of FDA approved testosterone supplementation exogenously as opposed to using off-label treatment strategies, while also preserving what fertility the treated subject has. Support of this hypothesis is needed from additional, longer duration studies utilizing short-acting testosterone. However, it is encouraging that studies performed to date tend to support the hypothesis. </em><span style="color: rgb(184, 49, 47)"><strong><em>The literature is well established that long-acting testosterone results in HPG suppression and resulting changes in physiology. Short-acting T therapy may be paradigm-changing for the treatment of T deficiency. </em></strong></span></p></blockquote><p></p>
[QUOTE="madman, post: 189846, member: 13851"] [B]Short-Acting Testosterone: Physiologic?[/B] [COLOR=rgb(44, 130, 201)]Gerwin Westfield, Ursula B Kaiser, Dolores J Lamb, Ranjith Ramasamy [/COLOR] [B]INTRODUCTION [/B] [COLOR=rgb(184, 49, 47)][I][B]Pulsatile secretion of a hormone refers to the intermittent secretion of the hormone in a burst like or episodic manner rather than constantly, with the frequency varying from minutes to hours, determined in part by the half-life of the hormone[/B][/I][B][I].[/I][/B][/COLOR][I] In men, communication between the hypothalamus, anterior pituitary, and testes via the hypothalamic-pituitary-gonadal (HPG) axis regulates testosterone (T) secretion, with a negative feedback mechanism controlling circulating levels of T (1). Pulsatile release of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons signals the pulsatile secretion of luteinizing hormone (LH) from the pituitary. Circulating LH, in turn, signals the testes to produce T. Once the appropriate threshold of circulating T levels is achieved, T acts as a negative feedback molecule, signaling to the hypothalamus and pituitary to inhibit secretion of GnRH and LH, respectively (2). [COLOR=rgb(184, 49, 47)][B]T levels in a healthy male follow a diurnal variation and circadian rhythm, with levels highest early in the morning and subsequently declining as the day progresses, as a direct result of pulsatile LH secretion (3).[/B][/COLOR][COLOR=rgb(0, 0, 0)] [I]T deficiency (TD) is a condition in which insufficient T levels are attained with one or more symptoms such as fatigue or low energy, depression, low libido, erectile dysfunction, and/or poor concentration (4). The Endocrine Society recently published treatment guidelines for men with symptomatic TD, which recommend a treatment goal of achieving steady-state serum total T concentrations in the mid-normal range (5).[/I][/COLOR][COLOR=rgb(184, 49, 47)][I] [B]A sustained steady-state level of T, however, differs from the normal circadian physiology of a healthy individual. [/B][/I][/COLOR]The most common hormone treatment for male hypogonadism is an intramuscular (IM) injectable generic testosterone cypionate/enanthate (72.8%), with other therapies including topical gel (25%), transdermal patch (1.2%), long-acting IM injections of testosterone undecanoate (0.18%), and nasal testosterone (0.13%) (6). [/I] [B]TESTOSTERONE PHARMACOKINETICS [/B] [I][COLOR=rgb(0, 0, 0)]The various testosterone formulations have a wide range of dosing intervals including long-acting preparations: subcutaneous pellets (3 to 6 months), injectable IM testosterone undecanoate (10 weeks); intermediate-acting preparations: IM testosterone cypionate/enanthate (1 to 3 weeks); daily preparations: topical/transdermal formulations; [/COLOR][/I][COLOR=rgb(0, 0, 0)][I]and short-acting preparations: oral testosterone undecanoate (twice daily) and nasal testosterone (two to three times daily).[/I][/COLOR] [COLOR=rgb(184, 49, 47)][I][B]All formulations, with the exception of the short-acting ones, have a [/B][U][B]target of long-term maintenance of sustained steady-state testosterone levels in the mid-normal range[/B][/U][B], which leads to suppression of the endogenous activity of the HPG axis.[/B][/I][/COLOR] [B][COLOR=rgb(184, 49, 47)][I]*[/I][/COLOR][COLOR=rgb(0, 0, 0)][I]As previously noted, testosterone levels in young healthy males follow a circadian rhythm. T levels are highest in the morning and lower in the evening hours. [/I][/COLOR][COLOR=rgb(184, 49, 47)][I][U]There is significant change within a 24-h period[/U].[/I][/COLOR][COLOR=rgb(0, 0, 0)][I] Testosterone itself acts as a negative feedback molecule to the hypothalamus and anterior pituitary. [/I][/COLOR][/B][COLOR=rgb(184, 49, 47)][I][U][B]When T levels are high enough, they signal to reduce GnRH, LH, and FSH secretion, thereby also reducing endogenous testosterone production. This occurs regardless of whether the circulating testosterone is endogenous or exogenous[/B][/U][B].[/B][/I][/COLOR][B][COLOR=rgb(0, 0, 0)][I] If high levels of testosterone are given exogenously for extended periods of time, this can result in negative feedback to the hypothalamus and anterior pituitary, disrupting normal HPG regulation. [/I][/COLOR][/B] [I]Topical gel formulations achieve a sustained mid-normal T level with a once-daily application (8). While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, the sustained T levels result in inhibition of HPG axis activity (9). The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9).[B] [/B][COLOR=rgb(184, 49, 47)][I][B]Nasal administration of T (4.5% testosterone nasal gel, Natesto) allows for rapid absorption through the nasal mucosa such that serum T levels reach a peak concentration in ∼40 min. Once in the circulation, the T is quickly metabolized, with a return to near baseline T levels in 3–6 h[/B] (11). Therefore, multiple administrations of nasal T throughout the day (three times daily) maintain normal mean serum T levels over 24 h. The fluctuations in T levels potentially minimize the duration of exposure to exogenous T that is suppressive to the HPG axis, compared to other available T therapies. [/I][/COLOR][/I] [B]FINAL THOUGHTS [/B] [COLOR=rgb(184, 49, 47)][B][I]Endocrine systems are regulated dynamically in response to positive or negative stimuli within a homeostatic environment. Modalities of T therapy evolved to extend the dosing interval and maintain sustained “steady-state” T levels. Long-acting TTh can inhibit the HPG axis, which in turn suppresses pituitary LH and FSH secretion, reducing circulating levels of LH and FSH and endogenous T production (Figure 1). [/I][/B][/COLOR][I][COLOR=rgb(44, 130, 201)][B][U]These endocrine changes result in suppression of spermatogenesis and infertility, as well as having other side effects[/U].[/B][/COLOR] The detrimental impact on sperm production from these long-acting testosterone therapies led to the use of many off-label products. The use of clomiphene citrate to stimulate gonadotropin production and subsequently increase testosterone levels is used to treat hypogonadism, while also trying to preserve fertility.[/I] [B][COLOR=rgb(184, 49, 47)][U][I]Short-acting T therapy, consisting of several doses of T with a shorter half-life throughout the day, minimizes inhibition of the HPG axis and reduces the impairment of spermatogenesis[/I][/U][I]. [/I][/COLOR][I][COLOR=rgb(44, 130, 201)]Utilizing FDA approved, shorter-acting forms of T therapy to maintain homeostasis that more closely reflects normal physiology offers great promise for the treatment of men with hypogonadism—an advantage over long-acting formulations. [/COLOR][/I][/B][I]This therapy would allow the use of FDA approved testosterone supplementation exogenously as opposed to using off-label treatment strategies, while also preserving what fertility the treated subject has. Support of this hypothesis is needed from additional, longer duration studies utilizing short-acting testosterone. However, it is encouraging that studies performed to date tend to support the hypothesis. [/I][COLOR=rgb(184, 49, 47)][B][I]The literature is well established that long-acting testosterone results in HPG suppression and resulting changes in physiology. Short-acting T therapy may be paradigm-changing for the treatment of T deficiency. [/I][/B][/COLOR] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Short-acting T therapy to maintain homeostasis that more closely reflects normal physiology
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