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I have it and I disagree, entirely, that low SHBG is a problem. You have to work with it, it dictates a different dosing and injection schedule and takes more care to manage E...high Free T is an absolute PLUS, but with it comes Free E. Smaller more frequent injections leads to high(er) TT and high Free T and likely no use of an AI.
I think that most that complain about it simply don't know that the standard E3.5D is not compatible for them and/or lack the ability to MAKE it work FOR THEM. Absent the discussion is Thyroid, Adrenals, and so forth that have to be investigated and treated if necessary but as a singular topic, SHBG is not bad.

I'm 10X better than I was as a Low T patient, but I test (often) got with Dr Saya, and I'm doing things to make it work, and doing things to get better still.

[QUOTE="Vince Carter, post: 34738, member: 2657"] I have it and I disagree, entirely, that low SHBG is a problem. You have to work with it, it dictates a different dosing and injection schedule and takes more care to manage E...high Free T is an absolute PLUS, but with it comes Free E. Smaller more frequent injections leads to high(er) TT and high Free T and likely no use of an AI. I think that most that complain about it simply don't know that the standard E3.5D is not compatible for them and/or lack the ability to MAKE it work FOR THEM. Absent the discussion is Thyroid, Adrenals, and so forth that have to be investigated and treated if necessary but as a singular topic, SHBG is not bad. I'm 10X better than I was as a Low T patient, but I test (often) got with Dr Saya, and I'm doing things to make it work, and doing things to get better still. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038