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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SHBG vs estrogen
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<blockquote data-quote="Cataceous" data-source="post: 203893" data-attributes="member: 38109"><p>There's a normal range for E2/T that's about 0.3-0.6%, which if inverted gives T/E2 of around 16-30 with conventional units. I've previously argued that lower SHBG may be problematic in part because the ratio of free estradiol to free testosterone increases as SHBG decreases, assuming free testosterone is held constant. Somebody recently asked me what happens with free DHT. The Multi-Ligand model suggests that free DHT increases significantly with decreasing SHBG. In theory this could somewhat offset the increase in free estradiol, but the serum levels of free DHT are still quite low relative to free testosterone, so the effect may be minor.</p><p></p><p>To answer your question, the theory and anecdotal reports seem to point to a lower E2/T—higher T/E2—ratio as perhaps better with low SHBG. There's even a rule of thumb out there saying that estradiol in pg/mL should be similar to SHBG in nMol/L. I'd view this as a last resort, however. Lower and more frequent dosing should be tried first. I'd also ensure progesterone is normal before messing with an AI.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 203893, member: 38109"] There's a normal range for E2/T that's about 0.3-0.6%, which if inverted gives T/E2 of around 16-30 with conventional units. I've previously argued that lower SHBG may be problematic in part because the ratio of free estradiol to free testosterone increases as SHBG decreases, assuming free testosterone is held constant. Somebody recently asked me what happens with free DHT. The Multi-Ligand model suggests that free DHT increases significantly with decreasing SHBG. In theory this could somewhat offset the increase in free estradiol, but the serum levels of free DHT are still quite low relative to free testosterone, so the effect may be minor. To answer your question, the theory and anecdotal reports seem to point to a lower E2/T—higher T/E2—ratio as perhaps better with low SHBG. There's even a rule of thumb out there saying that estradiol in pg/mL should be similar to SHBG in nMol/L. I'd view this as a last resort, however. Lower and more frequent dosing should be tried first. I'd also ensure progesterone is normal before messing with an AI. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SHBG vs estrogen
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