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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SHBG level inversely related to insulin level
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<blockquote data-quote="testiculus" data-source="post: 168034" data-attributes="member: 17128"><p>I haven't seen this mentioned previously. This suggests that those who are struggling with low SHBG should test for <a href="https://profgrant.com/2013/08/16/joseph-kraft-why-hyperinsulinemia-matters/" target="_blank">hyperinsulineamia</a>.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/7962291" target="_blank"><span style="font-size: 18px"><strong>The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss.</strong></span></a></p><p><span style="font-size: 12px"><span style="font-family: 'Verdana'">As SHBG is not known to alter the production or metabolism of insulin, whereas insulin has been shown in vitro to decrease the synthesis of SHBG, it seems a reasonable conclusion that the predictable inverse relationship between serum insulin and SHBG indicates that insulin controls SHBG synthesis in vivo. </span></span></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680959/" target="_blank"><span style="font-size: 18px"><strong>Inverse association between serum insulin and sex hormone-binding globulin</strong></span></a></p><p><span style="font-family: 'Verdana'">These findings are consistent with high levels of SHBG in T1D, and correspondingly low levels in T2D subjects, suggesting an inhibitory effect of insulin on the SHBG production in the liver.</span></p></blockquote><p></p>
[QUOTE="testiculus, post: 168034, member: 17128"] I haven't seen this mentioned previously. This suggests that those who are struggling with low SHBG should test for [URL='https://profgrant.com/2013/08/16/joseph-kraft-why-hyperinsulinemia-matters/']hyperinsulineamia[/URL]. [URL='https://www.ncbi.nlm.nih.gov/pubmed/7962291'][SIZE=18px][B]The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss.[/B][/SIZE][/URL] [SIZE=12px][FONT=Verdana]As SHBG is not known to alter the production or metabolism of insulin, whereas insulin has been shown in vitro to decrease the synthesis of SHBG, it seems a reasonable conclusion that the predictable inverse relationship between serum insulin and SHBG indicates that insulin controls SHBG synthesis in vivo. [/FONT][/SIZE] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680959/'][SIZE=18px][B]Inverse association between serum insulin and sex hormone-binding globulin[/B][/SIZE][/URL] [FONT=Verdana]These findings are consistent with high levels of SHBG in T1D, and correspondingly low levels in T2D subjects, suggesting an inhibitory effect of insulin on the SHBG production in the liver.[/FONT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SHBG level inversely related to insulin level
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