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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Shbg/free t?
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<blockquote data-quote="Cataceous" data-source="post: 211947" data-attributes="member: 38109"><p>You could make an argument for more testosterone being needed based on the statements below, which I've <a href="https://www.excelmale.com/forum/threads/how-to-lower-igf-1.20247/post-171531" target="_blank">quoted before</a>:</p><p></p><p style="margin-left: 20px"><em>However, new research shows that SHBG bound hormones are not only active, but that SHBG is itself a hormone with extracellular receptors ready to receive it. These receptors have been shown to modulate cAMP, which indirectly alters the sensitivity of the cell to the free hormones that enter it. </em></p><p></p><p style="margin-left: 20px"><em>More importantly, internalized SHBG functions within a cell to promote AR activity. Free hormone entering cells is less active without adequate SHBG also entering the cell, because they are rapidly metabolized and effluxed from the cell the same way that free hormones in serum are rapidly metabolized.</em></p><p></p><p style="margin-left: 20px"><em>CW is just plain wrong, and we've known it has been wrong. Yes, free hormones are "available" to enter cells ("bio-available",) but their ability to signal AR activity depends on the availability and uptake of free SHBG in many cell lines. This has been proven in studies: too much SHBG, and too little free hormone enters. Too little SHBG, and hormones won't last within the cell long enough, and cAMP will be attenuated, negating many of the effects of the hormone.</em></p> <p style="margin-left: 20px">[<a href="https://www.peaktestosterone.com/forum/index.php?topic=13367.15" target="_blank">R</a>]</p><p></p><p>Here's an underlying reference:</p><p></p><p style="margin-left: 20px"><em>Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, <strong>growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action</strong>. This study was to determine whether SHBG plays a role in testosterone uptake, metabolism, and action in the androgen sensitive LNCaP prostate cancer cell line. Internalisation of SHBG and testosterone, the effects of SHBG on testosterone uptake, metabolism, regulation of androgen responsive genes, and cell growth were assessed. <strong>LNCaP cells internalised SHBG by a testosterone independent process. Testosterone was rapidly taken up and effluxed as testosterone-glucuronide; however this effect was reduced by the presence of SHBG. ...</strong></em></p> <p style="margin-left: 20px">[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136390/" target="_blank">R</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 211947, member: 38109"] You could make an argument for more testosterone being needed based on the statements below, which I've [URL='https://www.excelmale.com/forum/threads/how-to-lower-igf-1.20247/post-171531']quoted before[/URL]: [INDENT][I]However, new research shows that SHBG bound hormones are not only active, but that SHBG is itself a hormone with extracellular receptors ready to receive it. These receptors have been shown to modulate cAMP, which indirectly alters the sensitivity of the cell to the free hormones that enter it. [/I][/INDENT] [INDENT][I]More importantly, internalized SHBG functions within a cell to promote AR activity. Free hormone entering cells is less active without adequate SHBG also entering the cell, because they are rapidly metabolized and effluxed from the cell the same way that free hormones in serum are rapidly metabolized.[/I][/INDENT] [INDENT][I]CW is just plain wrong, and we've known it has been wrong. Yes, free hormones are "available" to enter cells ("bio-available",) but their ability to signal AR activity depends on the availability and uptake of free SHBG in many cell lines. This has been proven in studies: too much SHBG, and too little free hormone enters. Too little SHBG, and hormones won't last within the cell long enough, and cAMP will be attenuated, negating many of the effects of the hormone.[/I] [[URL='https://www.peaktestosterone.com/forum/index.php?topic=13367.15']R[/URL]][/INDENT] Here's an underlying reference: [INDENT][I]Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones. However, [B]growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action[/B]. This study was to determine whether SHBG plays a role in testosterone uptake, metabolism, and action in the androgen sensitive LNCaP prostate cancer cell line. Internalisation of SHBG and testosterone, the effects of SHBG on testosterone uptake, metabolism, regulation of androgen responsive genes, and cell growth were assessed. [B]LNCaP cells internalised SHBG by a testosterone independent process. Testosterone was rapidly taken up and effluxed as testosterone-glucuronide; however this effect was reduced by the presence of SHBG. ...[/B][/I][/INDENT] [INDENT][[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136390/']R[/URL]][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Shbg/free t?
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