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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SHBG: Does it just bind and render androgens useless or does it have a purpose?
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<blockquote data-quote="johndoesmith" data-source="post: 60621" data-attributes="member: 13404"><p>SHBG is mentioned a LOT on this forum, and often many men are unhappy with their levels. Very few comments regarding SHBG are positive in nature, in fact SHBG is seen as a problem by many, and in the steroid community it is seen as something that needs to be lowered otherwise it'll "steal" all of your free testosterone. </p><p></p><p>SHBG levels are incredibly difficult to manipulate, as there are many many hormones involved in its regulation. [1]</p><p></p><p>SHBG has a role[2], a function[3], and even a receptor[4][5]. </p><p></p><p>In short, SHBG is quintessential to the proper hormonal functioning of men and women. Levels that are too low, or too high, have negative consequences, as always with hormones it is about balance. </p><p></p><p>[1] <a href="http://www.sciencedirect.com/science/article/pii/0960076091903102" target="_blank">http://www.sciencedirect.com/science/article/pii/0960076091903102</a></p><p>[2]<a href="http://dx.doi.org.sci-hub.cc/10.1016/1043-2760(95)00162-X" target="_blank">http://dx.doi.org.sci-hub.cc/10.1016/1043-2760(95)00162-X</a></p><p>[3] <a href="http://journals.sagepub.com/doi/pdf/10.1177/000456329002700603" target="_blank">http://journals.sagepub.com/doi/pdf/10.1177/000456329002700603</a></p><p>[4] <a href="http://www.jbc.org/content/265/11/6048.short" target="_blank">http://www.jbc.org/content/265/11/6048.short</a></p><p>[5] <a href="http://www.sciencedirect.com/science/article/pii/S0960076099000709" target="_blank">http://www.sciencedirect.com/science/article/pii/S0960076099000709</a></p><p></p><p>An interesting excerpt. </p><p></p><p></p><p><a href="http://journals.sagepub.com/doi/pdf/10.1177/000456329002700603" target="_blank">http://journals.sagepub.com/doi/pdf/10.1177/000456329002700603</a></p><p></p><p>For some fun filled reading, the free hormone hypothesis vs free hormone transport hypothesis is an entertaining and stimulating read. <a href="http://dx.doi.org.sci-hub.cc/10.1210/edrv-10-3-232" target="_blank">http://dx.doi.org.sci-hub.cc/10.1210/edrv-10-3-232</a></p></blockquote><p></p>
[QUOTE="johndoesmith, post: 60621, member: 13404"] SHBG is mentioned a LOT on this forum, and often many men are unhappy with their levels. Very few comments regarding SHBG are positive in nature, in fact SHBG is seen as a problem by many, and in the steroid community it is seen as something that needs to be lowered otherwise it'll "steal" all of your free testosterone. SHBG levels are incredibly difficult to manipulate, as there are many many hormones involved in its regulation. [1] SHBG has a role[2], a function[3], and even a receptor[4][5]. In short, SHBG is quintessential to the proper hormonal functioning of men and women. Levels that are too low, or too high, have negative consequences, as always with hormones it is about balance. [1] [URL]http://www.sciencedirect.com/science/article/pii/0960076091903102[/URL] [2][URL]http://dx.doi.org.sci-hub.cc/10.1016/1043-2760(95)00162-X[/URL] [3] [url]http://journals.sagepub.com/doi/pdf/10.1177/000456329002700603[/url] [4] [url]http://www.jbc.org/content/265/11/6048.short[/url] [5] [url]http://www.sciencedirect.com/science/article/pii/S0960076099000709[/url] An interesting excerpt. [URL]http://journals.sagepub.com/doi/pdf/10.1177/000456329002700603[/URL] For some fun filled reading, the free hormone hypothesis vs free hormone transport hypothesis is an entertaining and stimulating read. [URL]http://dx.doi.org.sci-hub.cc/10.1210/edrv-10-3-232[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SHBG: Does it just bind and render androgens useless or does it have a purpose?
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