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Nutrition and Supplements
SHBG Changes after Keto
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<blockquote data-quote="Cataceous" data-source="post: 252647" data-attributes="member: 38109"><p>Consider it a strong hypothesis, almost to the point of being a theory. [USER=38590]@readalot[/USER] points to support in the mechanistic literature, e.g. <a href="https://www.excelmale.com/forum/threads/chapter-12-hypothalamo-pituitary-unit-testis-and-male-accessory-organs.24827/post-217272" target="_blank">here</a>.</p><p></p><p>I have also argued directly for it like <a href="https://www.excelmale.com/forum/threads/freeing-up-testosterone-with-average-t-levels-and-or-higher-shbg.25063/post-220663" target="_blank">this</a>:</p><p></p><p style="margin-left: 20px">The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is matched by the rate of testosterone being metabolized and eliminated. 2) The rate of metabolism and elimination is proportional to the level of free testosterone, following the <a href="https://en.wikipedia.org/wiki/Law_of_mass_action" target="_blank">law of mass action</a>. A secondary assumption is that the underlying rate constant for metabolic clearance is relatively static. There are situations in which this constant changes dramatically, presumably including damage to the liver. But we'd hope these would not be common.</p><p></p><p style="margin-left: 20px">If the hypothesis is correct then it's clear that SHBG has little effect on free testosterone. ...</p><p></p><p>In your case I'd first ask if you are using an accurate test for free testosterone? An immunoassay-based test is inaccurate and unusable. Calculated free testosterone can be viable if SHBG isn't extreme. What is the biological basis for your view? Is it tied to the notion that testosterone production or dosing drives total testosterone? This is probably incorrect unless you can find a flaw in the above reasoning.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 252647, member: 38109"] Consider it a strong hypothesis, almost to the point of being a theory. [USER=38590]@readalot[/USER] points to support in the mechanistic literature, e.g. [URL='https://www.excelmale.com/forum/threads/chapter-12-hypothalamo-pituitary-unit-testis-and-male-accessory-organs.24827/post-217272']here[/URL]. I have also argued directly for it like [URL='https://www.excelmale.com/forum/threads/freeing-up-testosterone-with-average-t-levels-and-or-higher-shbg.25063/post-220663']this[/URL]: [INDENT]The working hypothesis is that in steady state conditions free testosterone is directly proportional to the production rate of endogenous testosterone, or to the dose rate of exogenous testosterone. Only two primary assumptions are necessary: 1) The rate of testosterone entering the system is matched by the rate of testosterone being metabolized and eliminated. 2) The rate of metabolism and elimination is proportional to the level of free testosterone, following the [URL='https://en.wikipedia.org/wiki/Law_of_mass_action']law of mass action[/URL]. A secondary assumption is that the underlying rate constant for metabolic clearance is relatively static. There are situations in which this constant changes dramatically, presumably including damage to the liver. But we'd hope these would not be common.[/INDENT] [INDENT]If the hypothesis is correct then it's clear that SHBG has little effect on free testosterone. ...[/INDENT] In your case I'd first ask if you are using an accurate test for free testosterone? An immunoassay-based test is inaccurate and unusable. Calculated free testosterone can be viable if SHBG isn't extreme. What is the biological basis for your view? Is it tied to the notion that testosterone production or dosing drives total testosterone? This is probably incorrect unless you can find a flaw in the above reasoning. [/QUOTE]
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SHBG Changes after Keto
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