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SHBG Changes after Keto
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<blockquote data-quote="Gus80" data-source="post: 251381" data-attributes="member: 45069"><p>Your SHBG is high but below the upper limit. About the studies, search Pubmed for "SGBH TRT" there are many studies on improvement in patients with high SHBG, but virtually nothing on TRT in low SHBG. Both testosterone and the DHT derivative considerably decrease SHBG, increasing Free Testosterone. I personally believe that it is much easier to manage patients with higher SHBG.</p><p>But it doesn't seem to be your case, you have excellent TT, FT, glycemia and insulin numbers. Your insulin is perfect! It has everything to benefit from a high carbohydrate diet combined with weight training. You missed measuring your Estradiol.</p><p>Do you have any symptoms?</p><p></p><p></p><p>Here are some natural suggestions for lowering SHBG.</p><p></p><h3>"1) Dietary Changes</h3><p>High-protein diets were associated with reduced blood SHBG levels in a study on over 1,500 men [<a href="https://www.ncbi.nlm.nih.gov/pubmed/10634401" target="_blank">95</a>].</p><p></p><p>In a clinical trial on 36 women, one cup of red wine daily reduced blood SHBG levels, while white wine did not [<a href="https://www.ncbi.nlm.nih.gov/pubmed/22150098" target="_blank">96</a>].</p><p></p><h3>2) Supplements</h3><p>The following supplements were found to decrease SHBG production and/or reduce its interaction with sex hormones, though further clinical studies are needed before these findings can be considered conclusive:</p><p></p><ul> <li data-xf-list-type="ul"><a href="https://selfhacked.com/blog/boron/" target="_blank">Boron</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/21129941" target="_blank">97</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/30037620" target="_blank">98</a>]</li> <li data-xf-list-type="ul"><a href="http://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/" target="_blank">Magnesium</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/19095394" target="_blank">99</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/29673411" target="_blank">100</a>]</li> <li data-xf-list-type="ul"><a href="https://selfhacked.com/blog/calcium-101/" target="_blank">Calcium</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/26254889" target="_blank">101</a>]</li> <li data-xf-list-type="ul"><a href="https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/" target="_blank">Zinc</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/26254889" target="_blank">101</a>, <a href="https://www.ncbi.nlm.nih.gov/pubmed/12943704" target="_blank">102</a>]</li> <li data-xf-list-type="ul"><a href="http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/" target="_blank">Vitamin D</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/21154195" target="_blank">103</a>]</li> <li data-xf-list-type="ul"><a href="http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/" target="_blank">Fish oil</a> (or any other polyunsaturated fatty acid supplements) [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11525593" target="_blank">104</a>]</li> <li data-xf-list-type="ul"><a href="https://selfhacked.com/blog/tongkat-ali/" target="_blank">Tongkat Ali</a> [<a href="https://www.ncbi.nlm.nih.gov/pubmed/23754792" target="_blank">105</a>]"</li> </ul><p></p><p>[URL unfurl="true"]https://labs.selfdecode.com/blog/sex-hormone-binding-globulin-shbg/#1_Dietary_Changes[/URL]</p></blockquote><p></p>
[QUOTE="Gus80, post: 251381, member: 45069"] Your SHBG is high but below the upper limit. About the studies, search Pubmed for "SGBH TRT" there are many studies on improvement in patients with high SHBG, but virtually nothing on TRT in low SHBG. Both testosterone and the DHT derivative considerably decrease SHBG, increasing Free Testosterone. I personally believe that it is much easier to manage patients with higher SHBG. But it doesn't seem to be your case, you have excellent TT, FT, glycemia and insulin numbers. Your insulin is perfect! It has everything to benefit from a high carbohydrate diet combined with weight training. You missed measuring your Estradiol. Do you have any symptoms? Here are some natural suggestions for lowering SHBG. [HEADING=2]"1) Dietary Changes[/HEADING] High-protein diets were associated with reduced blood SHBG levels in a study on over 1,500 men [[URL='https://www.ncbi.nlm.nih.gov/pubmed/10634401']95[/URL]]. In a clinical trial on 36 women, one cup of red wine daily reduced blood SHBG levels, while white wine did not [[URL='https://www.ncbi.nlm.nih.gov/pubmed/22150098']96[/URL]]. [HEADING=2]2) Supplements[/HEADING] The following supplements were found to decrease SHBG production and/or reduce its interaction with sex hormones, though further clinical studies are needed before these findings can be considered conclusive: [LIST] [*][URL='https://selfhacked.com/blog/boron/']Boron[/URL] [[URL='https://www.ncbi.nlm.nih.gov/pubmed/21129941']97[/URL], [URL='https://www.ncbi.nlm.nih.gov/pubmed/30037620']98[/URL]] [*][URL='http://selfhacked.com/blog/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks/']Magnesium[/URL] [[URL='https://www.ncbi.nlm.nih.gov/pubmed/19095394']99[/URL], [URL='https://www.ncbi.nlm.nih.gov/pubmed/29673411']100[/URL]] [*][URL='https://selfhacked.com/blog/calcium-101/']Calcium[/URL] [[URL='https://www.ncbi.nlm.nih.gov/pubmed/26254889']101[/URL]] [*][URL='https://selfhacked.com/blog/literally-everything-wanted-know-zinc-backed-science/']Zinc[/URL] [[URL='https://www.ncbi.nlm.nih.gov/pubmed/26254889']101[/URL], [URL='https://www.ncbi.nlm.nih.gov/pubmed/12943704']102[/URL]] [*][URL='http://selfhacked.com/blog/35proven-health-benefits-vitamin-d-part-1/']Vitamin D[/URL] [[URL='https://www.ncbi.nlm.nih.gov/pubmed/21154195']103[/URL]] [*][URL='http://selfhacked.com/blog/top-22-science-based-health-benefits-of-fish-oil/']Fish oil[/URL] (or any other polyunsaturated fatty acid supplements) [[URL='https://www.ncbi.nlm.nih.gov/pubmed/11525593']104[/URL]] [*][URL='https://selfhacked.com/blog/tongkat-ali/']Tongkat Ali[/URL] [[URL='https://www.ncbi.nlm.nih.gov/pubmed/23754792']105[/URL]]" [/LIST] [URL unfurl="true"]https://labs.selfdecode.com/blog/sex-hormone-binding-globulin-shbg/#1_Dietary_Changes[/URL] [/QUOTE]
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