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I wouldn't go so far as to say that something this far outside of normal physiology is necessarily benign, even if the bound testosterone is relatively inert. SHBG does have some other functions, which could be overdriven by the implied high levels. There's also the question of whether there's an underlying pathology driving the excess SHBG.

[QUOTE="Cataceous, post: 229733, member: 38109"] I wouldn't go so far as to say that something this far outside of normal physiology is necessarily benign, even if the bound testosterone is relatively inert. SHBG does have some other functions, which could be overdriven by the implied high levels. There's also the question of whether there's an underlying pathology driving the excess SHBG. [/QUOTE]