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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
SHBG: biomarker and hepatokine?
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<blockquote data-quote="madman" data-source="post: 201855" data-attributes="member: 13851"><p><strong>Figure 3. <u>The proposed role of the hypothalamic-pituitary-gonadal (HPG) axis in the regulation of free testosterone levels in men and women</u>. (A) In women, a genetic increase in serum sex hormone-binding globulin (SHBG) will result in a decrease in free testosterone. It is anticipated that this does not result in a feedback loop through the HPG axis, and hence total testosterone levels, which are independently regulated by the ovaries and adrenals, remain unaffected.</strong></p><p><strong></strong></p><p> <strong>(B) In men, a genetic increase in serum SHBG will decrease free testosterone levels. This initiates a feedback loop via the HPG axis, resulting in increased total testosterone levels and restoration of free testosterone levels. These biological mechanisms may explain the observations shown in Figure 2B, C, E, and F. Abbreviation: LH, luteinizing hormone.</strong></p><p><strong></strong></p><p><strong>[ATTACH=full]14528[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 201855, member: 13851"] [B]Figure 3. [U]The proposed role of the hypothalamic-pituitary-gonadal (HPG) axis in the regulation of free testosterone levels in men and women[/U]. (A) In women, a genetic increase in serum sex hormone-binding globulin (SHBG) will result in a decrease in free testosterone. It is anticipated that this does not result in a feedback loop through the HPG axis, and hence total testosterone levels, which are independently regulated by the ovaries and adrenals, remain unaffected. (B) In men, a genetic increase in serum SHBG will decrease free testosterone levels. This initiates a feedback loop via the HPG axis, resulting in increased total testosterone levels and restoration of free testosterone levels. These biological mechanisms may explain the observations shown in Figure 2B, C, E, and F. Abbreviation: LH, luteinizing hormone. [ATTACH type="full"]14528[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
SHBG: biomarker and hepatokine?
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